Insights into the Complexity of Primary Biliary Cholangitis and Autoimmune Hepatitis

Dear Colleagues,

Primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH) are chronic, immune-mediated liver diseases influenced by genetic, environmental and immunological factors. Despite progress in understanding and treating these conditions, challenges remain, including incomplete biochemical response, fibrosis progression and variant syndromes that complicate management. This Special Issue, “Insights into the Complexity of Primary Biliary Cholangitis and Autoimmune Hepatitis,” aims to expand current knowledge by inviting contributions on the molecular, immunological and clinical aspects of PBC and AIH. We particularly seek studies on immunopathogenesis, diagnostic and prognostic biomarkers, histopathological features, therapeutic targets and predictors of poor response to first-line treatments. Emphasizing a multidisciplinary approach, this issue encourages research that bridges hepatology, immunology, pathology and transplantation. Submissions may include original research, reviews or clinical studies focusing on disease mechanisms, biomarker discovery, variant syndromes, translational insights and emerging therapies, including post-transplant outcomes. Our goal is to promote a deeper understanding of autoimmune liver diseases and support the advancement of precision medicine through collaborative, interdisciplinary research.

Dr. Speranta Iacob
Prof. Dr. Liana Gheorghe
Prof. Dr. K. Rajender Reddy
Guest Editors

Manuscript Submission Information

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