Special Issue "Lipids and Glucose Physiopathology in Cardiovascular Disease and Hypertension"
A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425).
Deadline for manuscript submissions: 31 March 2020
Lipotoxicity has been emerging as important cardiovascular risk factor in patients with insulin resistance and visceral adiposity. Lipotoxicity consists of cell damage induced by lipid accumulation in non-adipose tissues, impaired cell function, and cellular death. Lipotoxicity has been involved in cardiomyopathies, heart failure, atrial fibrillation, atherosclerosis, and other cardiovascular diseases that often occur in overweight/obese, diabetic, or hypertensive patients. Although several observational studies have showed a relationship between adiposity, free fatty acids, insulin resistance and cardiovascular diseases, the molecular mechanisms of lipotoxicity are poorly understood. Insulin resistance is associated with increased plasma levels of free fatty acid and a lipid overflow into non-adipose tissues because of the inhibition of the anti-lipolytic action of insulin. The chronic accumulation of fatty acids and their products, diacylglycerols and ceramides, in adipocytes produces the release of adipocytokines and inflammatory mediators that activate subclinical inflammation and oxidative stress. This inflammatory and oxidative environment is thought to be responsible for the initial endothelial dysfunction and the subsequent development of cardiovascular tissue impairment. The aim of this Special Issue is to deepen the physiopathological basis of lipotoxicity by providing experimental studies, clinical observations, or interventional trials that could elucidate the link between alterations of lipids and glucose metabolism, cardiovascular diseases, and hypertension.
Dr. GianLuca Colussi
Manuscript Submission Information
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- insulin resistance
- fatty acids