Special Issue "Leaders in Cardiovascular Research: A special issue dedicated to Professor Antoon Moorman"

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425).

Deadline for manuscript submissions: closed (1 May 2019).

Special Issue Editors

Guest Editor
Dr. Maurice Van den Hoff

Academic Medical Center, Department of Medical Biology, Meibergdreef 15, 1105AZ Amsterdam, The Netherlands
Website | E-Mail
Interests: cardiovascular development; epicardium development; myocardium formation; cell signalling; BMP signalling; molecular biology; transgenic mice; congenital cardiac abnormalities
Guest Editor
Dr. Robert G. Kelly

Developmental Biology Institute of Marseille, CNRS UMR 7288, Aix-Marseille University, France
Website | E-Mail
Interests: early heart development; cardiac progenitor cells; pharyngeal development; outflow tract morphogenesis; ventricular conduction system; craniofacial myogenesis; T-box genes

Special Issue Information

Dear Colleagues,

Over the next few years the Journal of Cardiovascular Development and Disease (JCDD) is planning a series of special issues entitled “Leaders in Cardiovascular Research” in which we will highlight the work and achievements of outstanding and unique researchers that have made major and often paradigm shifting contributions to the field.

The first publication in this series will focus on the accomplishments of Prof. Antoon Moorman, a pioneer in the field of heart development who retired in 2012 from his position as Professor and Chair of the Department of Anatomy, Embryology and Physiology at the University of Amsterdam. As the leader of a productive and dynamic group of young investigators in Amsterdam, Prof. Moorman was the driving force behind many multidisciplinary studies that, over the years, have significantly changed and improved our understanding of the development of the four-chambered heart.

This commemorative issue will contain a series of commissioned scientific papers and reviews on topics pioneered by Prof. Moorman. In addition, authors interested in participating in this special issue on any topic in which the work of Prof. Moorman has been instrumental are invited to contact the Guest Editors.

Dr. Maurice J.B. van den Hoff
Dr. Robert G. Kelly
Gues Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Cardiac morphogenesis
  • Cardiac evolution
  • Cardiac conduction system ontogeny and evolution
  • Cardiac physiology
  • Technical innovations applied to the study of cardiac anatomy

Published Papers (4 papers)

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Research

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Open AccessArticle
Analysis of Uncharacterized mKiaa1211 Expression during Mouse Development and Cardiovascular Morphogenesis
J. Cardiovasc. Dev. Dis. 2019, 6(2), 24; https://doi.org/10.3390/jcdd6020024
Received: 17 May 2019 / Revised: 13 June 2019 / Accepted: 19 June 2019 / Published: 22 June 2019
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Abstract
Mammalian Kiaa1211 and Kiaa1211-like are a homologous pair of uncharacterized, highly conserved genes cloned from fetal and adult brain cDNA libraries. Herein we map the in utero spatiotemporal expression of mKiaa1211 and mKiaa1211L mRNA and their expression patterns in postnatal testis, skin, gastrointestinal, [...] Read more.
Mammalian Kiaa1211 and Kiaa1211-like are a homologous pair of uncharacterized, highly conserved genes cloned from fetal and adult brain cDNA libraries. Herein we map the in utero spatiotemporal expression of mKiaa1211 and mKiaa1211L mRNA and their expression patterns in postnatal testis, skin, gastrointestinal, and adipose progenitor tissues. Significantly, mKiaa1211 is present throughout the early stages of mouse heart development, particularly in the second heart field (SHF) lineage as it differentiates from mesenchymal cells into cardiomyocytes. We also show that mKiaa1211 is expressed within several early neuronal tissues destined to give rise to central, peripheral, and sympathetic nervous system structures. Expression profiling revealed that the paralog mKiaa1211L is not expressed during the normal developmental process and that mKiaa1211 expression was noticeably absent from most adult terminally differentiated tissues. Finally, we confirm that a previously uncharacterized CRISPR/CAS-generated mKiaa1211 mouse mutant allele is hypomorphic. Full article
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Review

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Open AccessFeature PaperReview
The Anatomy, Development, and Evolution of the Atrioventricular Conduction Axis
J. Cardiovasc. Dev. Dis. 2018, 5(3), 44; https://doi.org/10.3390/jcdd5030044
Received: 10 August 2018 / Revised: 16 August 2018 / Accepted: 19 August 2018 / Published: 22 August 2018
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Abstract
It is now well over 100 years since Sunao Tawara clarified the location of the axis of the specialised myocardium responsible for producing coordinated ventricular activation. Prior to that stellar publication, controversies had raged as to how many bundles crossed the place of [...] Read more.
It is now well over 100 years since Sunao Tawara clarified the location of the axis of the specialised myocardium responsible for producing coordinated ventricular activation. Prior to that stellar publication, controversies had raged as to how many bundles crossed the place of the atrioventricular insulation as found in mammalian hearts, as well as the very existence of the bundle initially described by Wilhelm His Junior. It is, perhaps surprising that controversies continue, despite the multiple investigations that have taken place since the publication of Tawara’s monograph. For example, we are still unsure as to the precise substrates for the so-called slow and fast pathways into the atrioventricular node. Much has been done, nonetheless, to characterise the molecular make-up of the specialised pathways, and to clarify their mechanisms of development. Of this work itself, a significant part has emanated from the laboratory coordinated for a quarter of a century by Antoon FM Moorman. In this review, which joins the others in recognising the value of his contributions and collaborations, we review our current understanding of the anatomy, development, and evolution of the atrioventricular conduction axis. Full article
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Open AccessFeature PaperReview
Growth and Morphogenesis during Early Heart Development in Amniotes
J. Cardiovasc. Dev. Dis. 2017, 4(4), 20; https://doi.org/10.3390/jcdd4040020
Received: 15 October 2017 / Revised: 17 November 2017 / Accepted: 17 November 2017 / Published: 22 November 2017
Cited by 2 | PDF Full-text (1823 KB) | HTML Full-text | XML Full-text
Abstract
In this review, we will focus on the growth and morphogenesis of the developing heart, an aspect of cardiovascular development to which Antoon Moorman and colleagues have extensively contributed. Over the last decades, genetic studies and characterization of regionally regulated gene programs have [...] Read more.
In this review, we will focus on the growth and morphogenesis of the developing heart, an aspect of cardiovascular development to which Antoon Moorman and colleagues have extensively contributed. Over the last decades, genetic studies and characterization of regionally regulated gene programs have provided abundant novel insights into heart development essential to understand the basis of congenital heart disease. Heart morphogenesis, however, is inherently a complex and dynamic three-dimensional process and we are far from understanding its cellular basis. Here, we discuss recent advances in studying heart morphogenesis and regionalization under the light of the pioneering work of Moorman and colleagues, which allowed the reinterpretation of regional gene expression patterns under a new morphogenetic framework. Two aspects of early heart formation will be discussed in particular: (1) the initial formation of the heart tube and (2) the formation of the cardiac chambers by the ballooning process. Finally, we emphasize that in addition to analyses based on fixed samples, new approaches including clonal analysis, single-cell sequencing, live-imaging and quantitative analysis of the data generated will likely lead to novel insights in understanding early heart tube regionalization and morphogenesis in the near future. Full article
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Open AccessReview
Current Perspectives in Cardiac Laterality
J. Cardiovasc. Dev. Dis. 2016, 3(4), 34; https://doi.org/10.3390/jcdd3040034
Received: 19 September 2016 / Revised: 23 November 2016 / Accepted: 5 December 2016 / Published: 9 December 2016
Cited by 8 | PDF Full-text (856 KB) | HTML Full-text | XML Full-text
Abstract
The heart is the first organ to break symmetry in the developing embryo and onset of dextral looping is the first indication of this event. Looping is a complex process that progresses concomitantly to cardiac chamber differentiation and ultimately leads to the alignment [...] Read more.
The heart is the first organ to break symmetry in the developing embryo and onset of dextral looping is the first indication of this event. Looping is a complex process that progresses concomitantly to cardiac chamber differentiation and ultimately leads to the alignment of the cardiac regions in their final topology. Generation of cardiac asymmetry is crucial to ensuring proper form and consequent functionality of the heart, and therefore it is a highly regulated process. It has long been known that molecular left/right signals originate far before morphological asymmetry and therefore can direct it. The use of several animal models has led to the characterization of a complex regulatory network, which invariably converges on the Tgf-β signaling molecule Nodal and its downstream target, the homeobox transcription factor Pitx2. Here, we review current data on the cellular and molecular bases of cardiac looping and laterality, and discuss the contribution of Nodal and Pitx2 to these processes. A special emphasis will be given to the morphogenetic role of Pitx2 and to its modulation of transcriptional and functional properties, which have also linked laterality to atrial fibrillation. Full article
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J. Cardiovasc. Dev. Dis. EISSN 2308-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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