The Anatomy, Development, and Evolution of the Atrioventricular Conduction Axis
AbstractIt is now well over 100 years since Sunao Tawara clarified the location of the axis of the specialised myocardium responsible for producing coordinated ventricular activation. Prior to that stellar publication, controversies had raged as to how many bundles crossed the place of the atrioventricular insulation as found in mammalian hearts, as well as the very existence of the bundle initially described by Wilhelm His Junior. It is, perhaps surprising that controversies continue, despite the multiple investigations that have taken place since the publication of Tawara’s monograph. For example, we are still unsure as to the precise substrates for the so-called slow and fast pathways into the atrioventricular node. Much has been done, nonetheless, to characterise the molecular make-up of the specialised pathways, and to clarify their mechanisms of development. Of this work itself, a significant part has emanated from the laboratory coordinated for a quarter of a century by Antoon FM Moorman. In this review, which joins the others in recognising the value of his contributions and collaborations, we review our current understanding of the anatomy, development, and evolution of the atrioventricular conduction axis. View Full-Text
Share & Cite This Article
Anderson, R.H.; Mori, S.; Spicer, D.E.; Sanchez-Quintana, D.; Jensen, B. The Anatomy, Development, and Evolution of the Atrioventricular Conduction Axis. J. Cardiovasc. Dev. Dis. 2018, 5, 44.
Anderson RH, Mori S, Spicer DE, Sanchez-Quintana D, Jensen B. The Anatomy, Development, and Evolution of the Atrioventricular Conduction Axis. Journal of Cardiovascular Development and Disease. 2018; 5(3):44.Chicago/Turabian Style
Anderson, Robert H.; Mori, Shumpei; Spicer, Diane E.; Sanchez-Quintana, Damian; Jensen, Bjarke. 2018. "The Anatomy, Development, and Evolution of the Atrioventricular Conduction Axis." J. Cardiovasc. Dev. Dis. 5, no. 3: 44.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.