Proteomics and Protein Post-Translational Modification

Dear Colleagues,

JCDD is launching a Special Issue on "Proteomics and Protein Post-Translational Modification in Heart Disease". Post-translational modifications (PTMs) have been shown to alter protein function by creating new protein binding sites, abrogating protein–protein interactions, or inducing allosteric regulation. Furthermore, the rapid and transient nature of many PTMs allow efficient signal transmission in response to internal and environmental stimuli. PTMs are predominantly triggered by enzymes, and the enzymes responsible are thus attractive targets for therapeutic interventions. Modifications can be grouped according to their stability or transience (reversible versus irreversible): Irreversible types (such as irreversible redox modifications or protein deamidation) are often associated with aging or tissue injury, whereas transient modifications are associated with signal propagation and regulation. This is particularly important in the setting of heart disease, which comprises a diverse range of acute (such as ischemia/reperfusion), chronic (such as heart failure, dilated cardiomyopathy) and genetic (such as hypertrophic cardiomyopathy) disease states, all of which have been associated with protein PTM. This field is rapidly evolving, using multiple approaches, including but not restricted to computational biology, protein arrays, and biochemical analyses, proteomic mapping, molecular and transgenic techniques both in vivo and in vitro. This interesting combination of applications allows for new interpretations and analyses for understanding the evolutionary, developmental and functional therapeutic potential in the setting of heart disease.

Dr. Chang Won Kho
Dr. Kiyotake Ishikawa
Guest Editors

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