Food, Drugs and Environmental Exposures as Triggers of Myocardial Injury and Myocardial Infarction

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425). This special issue belongs to the section "Basic and Translational Cardiovascular Research".

Deadline for manuscript submissions: closed (31 January 2025) | Viewed by 9588

Special Issue Editor


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Guest Editor
Department of Cardiology, University of Patras Medical School, 26221 Patras, Greece
Interests: Kounis syndrome; coronary artery disease; coronary artery spasm; myocardial ischemia
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Hippocrates, the father of Medicine, once said “Let food be your medicine and medicine be your food.” Indeed, there are important and significant associations between the frequency of one’s consumption of specific foods and the subsequent risk of myocardial infarction. The role of food in health has been evidenced via epidemiological observations and associated studies, in which a single or limited number of foods have demonstrated the diet–disease relationships. Environmental factors, and diet in particular, are known to play a key role in the development of coronary artery disease. Many of these factors have been unveiled by nutritional observations, focusing on the role of a single nutrient or food.

Moreover, therapeutic and illicit drug use are documented and lead to the consideration of alternative pathophysiologic rationales for myocardial infarction. The drugs employed for the treatment of cancer, central nervous system stimulants, allergy-induced medications and a plethora of other drugs with cytotoxic and hypersensitivity actions possess the potential to induce myocardial damage.

Growing evidence suggests that there is an association between exposure to ambient air pollution, household air pollution from biomass fuel, lead, arsenic, and cadmium and multiple cardiovascular disease outcomes, including myocardial damage, hypertension, coronary heart disease, stroke, and cardiovascular mortality. The aim of this Special Issue is to describe the association between foods, drugs and the environment, and coronary damage and disease. This will improve the knowledge, prevention and treatment of these frequent daily exposures.

Prof. Dr. Nicholas G Kounis
Guest Editor

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Keywords

  • myocardial injury
  • myocardial infarction
  • diet
  • drugs
  • environmental exposures

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Published Papers (2 papers)

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Review

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19 pages, 658 KiB  
Review
Drug-Induced Myocardial Infarction: A Review of Pharmacological Triggers and Pathophysiological Mechanisms
by Ioana Boarescu and Paul-Mihai Boarescu
J. Cardiovasc. Dev. Dis. 2024, 11(12), 406; https://doi.org/10.3390/jcdd11120406 - 18 Dec 2024
Cited by 1 | Viewed by 7043
Abstract
Myocardial infarction (MI) is a significant cardiovascular event caused by the decrease in or complete cessation of blood flow to a portion of the myocardium. It can arise from a variety of etiological factors, including pharmacological triggers. This review aims to explore the [...] Read more.
Myocardial infarction (MI) is a significant cardiovascular event caused by the decrease in or complete cessation of blood flow to a portion of the myocardium. It can arise from a variety of etiological factors, including pharmacological triggers. This review aims to explore the diverse drugs and substances that might lead to drug-induced myocardial infarction, focusing on their mechanisms of action and the pathophysiological processes involved. Various established and emerging pharmacological agents that could elevate the risk of myocardial infarction, such as nonsteroidal anti-inflammatory drugs, hormonal therapies, anticoagulants, and antipsychotic medications, are discussed. The role of drug-induced endothelial dysfunction, coronary artery spasm, and thrombosis are presented in order to highlight the underlying mechanisms. This review emphasizes the need for increased awareness among healthcare professionals to mitigate the risks associated with different pharmacological therapies to improve patient outcomes. Full article
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15 pages, 3197 KiB  
Systematic Review
Effect of Coenzyme Q10 Supplementation on Lipid and Glycaemic Profiles: An Umbrella Review
by Silvana Patiño-Cardona, Miriam Garrido-Miguel, Carlos Pascual-Morena, Carlos Berlanga-Macías, Maribel Lucerón-Lucas-Torres, Sofía Alfaro-González and Irene Martínez-García
J. Cardiovasc. Dev. Dis. 2024, 11(12), 377; https://doi.org/10.3390/jcdd11120377 - 25 Nov 2024
Cited by 1 | Viewed by 2243
Abstract
Coenzyme Q10 (CoQ10) has been suggested as an adjunct therapy for endocrine and metabolic disorders. The aim of this study was to synthesise the evidence for the effect of CoQ10 supplementation on lipid and/or glycaemic alterations, including total cholesterol (TC), LDL- and HDL-cholesterol [...] Read more.
Coenzyme Q10 (CoQ10) has been suggested as an adjunct therapy for endocrine and metabolic disorders. The aim of this study was to synthesise the evidence for the effect of CoQ10 supplementation on lipid and/or glycaemic alterations, including total cholesterol (TC), LDL- and HDL-cholesterol (LDL-C and HDL-C), lipoprotein a, fasting blood glucose (FBG), haemoglobin A1c (HbA1c), fasting insulin and Homeostatic Model Assessment of Insulin Resistance. A systematic search was conducted in Medline, Scopus, Web of Science and the Cochrane Library from their inception to July 2024. Meta-analyses that evaluated the effect of CoQ10 on the lipid or glycaemic profiles were included. Results were expressed as mean difference (MD) or standardised mean difference (SMD). CoQ10 showed an effect on the glycaemic profile, especially on FBG (MD from −11.21 to −5.2 mg/dL, SMD from −2.04 to −0.17) and on HbA1c (MD from −1.83 to −0.12%, SMD of −0.30). CoQ10 may also have an effect on the lipid profile, such as TC, triglycerides, HDL-C and even LDL-C, although the inconsistency of the results was somewhat higher. Supplementation with CoQ10 may be beneficial, especially in populations with diabetes mellitus or other endocrine and metabolic disorders. It could also have some effect on lipid parameters, which, together with the above, may reduce cardiovascular morbidity and mortality, although this is something that needs further research. Full article
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