Innovative Trends in Cardiovascular Medicine and Surgery

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425). This special issue belongs to the section "Cardiovascular Clinical Research".

Deadline for manuscript submissions: 15 June 2025 | Viewed by 4257

Special Issue Editors


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Guest Editor
1. Cardiovascular Service Line, Virtua Health, Marlton, NJ 08053, USA
2. Department of Cardiothoracic Surgery, Virtua Our Lady of Lourdes Hospital, Camden, NJ 08013, USA
Interests: adult cardiovascular surgery; advanced heart failure; heart transplantation; machine learning
Division of Cardiac Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Interests: aortic stenosis; cardiac surgery; coronary artery bypass graft surgery (CABG); coronary artery disease; transcatheter aortic valve replacement (TAVR); valvular heart surgery

Special Issue Information

Dear Colleagues,

Cardiovascular medicine and surgery remain at the forefront of clinical innovation in the midst of a rapidly evolving field of medicine at large. With the advent of digital technology, the pace at which novel techniques and knowledge are introduced to specialties is increasing exponentially.

In the last several years, there have been many major milestones that have changed the delivery of cardiovascular care to patients, including transcatheter valves or structural heart interventions, non-invasive digital hemodynamic monitors, minimally invasive surgical platforms, and artificial intelligence.

This Special Issue of JCDD will highlight and showcase the latest innovations that are promoting the most advanced iterations of clinical research and experimental concepts in cardiovascular specialties.

Dr. Chun Woo Choi
Dr. Hamza Aziz
Guest Editors

Manuscript Submission Information

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Keywords

  • cardiovascular
  • cardiac surgery
  • innovation
  • translational science
  • machine learning
  • artificial intelligence

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Published Papers (2 papers)

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Research

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13 pages, 9949 KiB  
Article
Cerebral Embolic Protection in Patients Undergoing Left Atrial Appendage Closure
by Julia Seeger, Philipp Seppelt, Mario Iturbe-Orbe, David Leistner, Jochen Wöhrle and Michael Joner
J. Cardiovasc. Dev. Dis. 2025, 12(1), 5; https://doi.org/10.3390/jcdd12010005 - 26 Dec 2024
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Abstract
(1) Background: Cerebral magnetic resonance imaging has reported new cerebral ischemic lesions after left atrial appendage (LAA) closure in about one- third of patients. Stroke occurs predominantly periprocedurally. This study evaluated the characteristics of embolized debris captured by the SENTINELTM cerebral embolic [...] Read more.
(1) Background: Cerebral magnetic resonance imaging has reported new cerebral ischemic lesions after left atrial appendage (LAA) closure in about one- third of patients. Stroke occurs predominantly periprocedurally. This study evaluated the characteristics of embolized debris captured by the SENTINELTM cerebral embolic protection system in patients undergoing LAA closure; (2) Methods: Sixty filters of 30 consecutive patients undergoing LAA closure with the WATCHMAN FLXTM device were collected and captured debris was analyzed by histopathology and histomorphometry. Clinical outcome measures were disabling and non-disabling stroke within 72 h; (3) Results: In most filters, no material was captured. The predominant captured debris was acute or organized thrombi. The most common pattern was acute fibrin-rich thrombus, which was detected in 11/30 (33.3%) patients. Particles of heart tissue were seen in 6/30 (20%) patients, and foreign material was seen in one (3.3%) patient. The number of particles ranged from 0 to 52 per patient with a maximum of 31 in the distal and 21 in the proximal filter. Particle diameter ranged from 131 to 2614 µm. By logistic regression analysis, only protected time remained a multivariable predictor for larger particles (p = 0.039). There was no disabling or non-disabling stroke. Compared to transfemoral aortic valve replacement, the number of particles is only about 1.5%. (4) Conclusion: LAA occlusion with the WATCHMAN FLXTM was associated with a very low number of embolized particles captured with the double-filter SENTINELTM embolic protection system and no periprocedural stroke. Full article
(This article belongs to the Special Issue Innovative Trends in Cardiovascular Medicine and Surgery)
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Review

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18 pages, 1729 KiB  
Review
Rheumatic and Degenerative Mitral Stenosis: From an Iconic Clinical Case to the Literature Review
by Francesca Napoli, Ciro Vella, Luca Ferri, Marco B. Ancona, Barbara Bellini, Filippo Russo, Eustachio Agricola, Antonio Esposito and Matteo Montorfano
J. Cardiovasc. Dev. Dis. 2024, 11(5), 153; https://doi.org/10.3390/jcdd11050153 - 17 May 2024
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Abstract
Mitral stenosis (MS) poses significant challenges in diagnosis and management due to its varied etiologies, such as rheumatic mitral stenosis (RMS) and degenerative mitral stenosis (DMS). While rheumatic fever-induced RMS has declined in prevalence, DMS is rising with aging populations and comorbidities. Starting [...] Read more.
Mitral stenosis (MS) poses significant challenges in diagnosis and management due to its varied etiologies, such as rheumatic mitral stenosis (RMS) and degenerative mitral stenosis (DMS). While rheumatic fever-induced RMS has declined in prevalence, DMS is rising with aging populations and comorbidities. Starting from a complex clinical case of DMS, the aim of this paper is to review the literature on mitral stenosis by analyzing the available tools and the differences in terms of diagnosis and treatment for rheumatic and degenerative stenosis. Emerging transcatheter techniques, such as transcatheter mitral valve replacement (TMVR) and lithotripsy-facilitated percutaneous mitral commissurotomy (PMC), represent promising alternatives for DMS patients deemed unfit for surgery. In particular, intravascular lithotripsy (IVL) has shown potential in facilitating percutaneous interventions by fracturing calcific deposits and enabling subsequent interventions. However, larger prospective studies are warranted to validate these findings and establish IVL’s role in DMS management. To further enhance this technique, research could focus on investigating the long-term outcomes and durability of mitral lithotripsy, as well as exploring its potential in combination with PMC or TMVR. Full article
(This article belongs to the Special Issue Innovative Trends in Cardiovascular Medicine and Surgery)
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