Clinical Outcome and Treatment of Cardiac Arrest

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425). This special issue belongs to the section "Electrophysiology and Cardiovascular Physiology".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 2532

Special Issue Editor


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Guest Editor
Department of Cardiology, Nihon University Hospital, Tokyo 101‐8309, Japan
Interests: cardiac arrest; resuscitation science; post-cardiac arrest care; heart failure; cardiac rehabilitation

Special Issue Information

Dear Colleagues,

This Special Issue on “Clinical Outcome and Treatment of Cardiac Arrest" aims to serve as a seminal resource for medical professionals navigating the evolving landscape of cardiac arrest care. Despite advancements in resuscitative science, cardiac arrest continues to be a leading cause of mortality and morbidity around the world. This Special Issue seeks to address this critical gap by focusing on two pivotal aspects: prognostic performance and management strategies. It aims to elucidate the latest predictive models and biomarkers that can accurately forecast patient outcomes following resuscitation. Concurrently, the Special Issue will explore innovative management approaches, from pre-hospital interventions to advanced critical care techniques, that optimize patient survival and neurological function. By amalgamating cutting-edge research and expert opinions, this Special Issue endeavors to enhance clinical decision making and set new benchmarks in cardiac arrest care. The target audience comprises basic researchers, resuscitation scientists, emergency physicians, intensivists, cardiologists, and other healthcare providers who are committed to elevating the standard of care in this life-threatening condition.

Dr. Tsukasa Yagi
Guest Editor

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Keywords

  • cardiac arrest
  • post-cardiac arrest syndrome
  • cardiogenic shock
  • post-cardiac-arrest care
  • resuscitation science

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Published Papers (1 paper)

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Research

10 pages, 1130 KB  
Article
Exploratory Study of Selective Brain Hypothermia Using Transnasal Evaporative Cooling Under Controlled Normothermia with an Endovascular Device
by Mitsuaki Nishikimi, Kazuya Kikutani, Mayumi Higashi, Shinichiro Ohshimo, Tatsuhiko Anzai and Nobuaki Shime
J. Cardiovasc. Dev. Dis. 2026, 13(3), 120; https://doi.org/10.3390/jcdd13030120 - 6 Mar 2026
Viewed by 861
Abstract
Introduction: Selective brain hypothermia has been investigated to improve neurological outcomes in patients with cardiac arrest; however, an optimal clinical method has not yet been established. This study aimed to evaluate the feasibility of a technique combining transnasal evaporative cooling with simultaneous endovascular [...] Read more.
Introduction: Selective brain hypothermia has been investigated to improve neurological outcomes in patients with cardiac arrest; however, an optimal clinical method has not yet been established. This study aimed to evaluate the feasibility of a technique combining transnasal evaporative cooling with simultaneous endovascular temperature management to achieve selective brain hypothermia while preventing systemic hypothermia. Methods: Three adult male Göttingen swine were anesthetized and mechanically ventilated. Transnasal cooling was initiated at maximum output while endovascular warming preserved systemic temperature. Brain parenchymal and rectal temperatures, mean arterial pressure (MAP), heart rate (HR), and cardiac output (CO) were continuously monitored for 60 min. Temperature differences between brain and rectum at 60 min were analyzed. Results: A brain–rectal gradient ≥1.0 °C was achieved in all swine at 25, 40, and 30 min, respectively, and maintained at 1.0–1.5 °C thereafter. Brain temperature (34.5 ± 0.34 °C) was significantly lower than rectal temperature (35.8 ± 0.35 °C) at 60 min after initiation of the selective cooling procedure (p = 0.0048). MAP, HR, and CO showed no deviations from baseline. Conclusions: The combination of transnasal cooling and endovascular warming reliably induced selective brain hypothermia of 1–1.5 °C without adverse effects on hemodynamic parameters in swine. Full article
(This article belongs to the Special Issue Clinical Outcome and Treatment of Cardiac Arrest)
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