Stroke in the Young

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425). This special issue belongs to the section "Stroke and Cerebrovascular Disease".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 537

Special Issue Editor

Special Issue Information

Dear Colleagues,

Stroke is a major cause of death and disability globally. Approximately 10–15% of strokes occur among those aged below 50 years. Stroke in the young (SITY) may affect neonates, children, and young adults. Compared to stroke in older adults, SITY may be due to different risk factors and mechanisms, and carries a different prognosis. Generally having a lower mortality, individuals presenting as SITY may live longer, but show disability that can impact on their quality of life, relationships, employment, leisure, driving, and even more so if there are post-stroke complications such as seizures or cognitive impairment. Families and loved ones are impacted too. The many clinical trials in stroke treatment largely involve older adults, and may be less applicable to SITY.

We welcome original contributions to this Special Issue on stroke in the young, especially papers showcasing the challenges in managing these young individuals as they face life after their stroke.

Dr. Narayanaswamy Venketasubramanian
Guest Editor

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Keywords

  • young
  • neonate
  • child
  • cerebrovascular disease
  • stroke
  • cerebral infarction
  • intracerebral haemorrhage
  • subarachnoid haemorrhage
  • risk factors
  • mechanisms
  • prognosis
  • outcomes
  • complications

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Published Papers (1 paper)

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Review

29 pages, 3375 KiB  
Review
Spontaneous Intracranial Vertebral Artery Dissection: A Rare Cause of Ischemic Stroke
by Marialuisa Zedde and Rosario Pascarella
J. Cardiovasc. Dev. Dis. 2025, 12(5), 187; https://doi.org/10.3390/jcdd12050187 - 15 May 2025
Viewed by 217
Abstract
The dissection of the V4 vertebral artery (VA) is the most prevalent form of intracranial dissection, which can manifest either as ischemia or as a subarachnoid hemorrhage (SAH). Patient outcomes are significantly affected by their initial presentation; ischemic symptoms often indicate that the [...] Read more.
The dissection of the V4 vertebral artery (VA) is the most prevalent form of intracranial dissection, which can manifest either as ischemia or as a subarachnoid hemorrhage (SAH). Patient outcomes are significantly affected by their initial presentation; ischemic symptoms often indicate that the dissection remains primarily subintimal or within the medial layer, though it can occasionally extend to the basilar artery. In contrast, patients with ruptured VA dissection (VAD) experience a considerably higher mortality rate, as the dissection can reach the adventitial layer, heightening the risk of recurrent hemorrhage. It can show fluctuating imaging findings, making an accurate diagnosis and timely treatment essential. Currently, there are no established diagnostic criteria for VAD, and its diagnosis largely depends on imaging. The presence of intramural hematoma, identified via three-dimensional, black-blood, T1-weighted imaging, has been recognized as the most reliable indicator for diagnosing VAD and is crucial for establishing a definitive diagnosis. DSA remains a fundamental diagnostic technique not only in hemorrhagic patients but also in ischemic patients. The medical treatment of ischemic patients has not yet been well defined, and evidence-based data are lacking. This review aims to summarize the main clinical, pathophysiological, and neuroradiological features of intracranial VAD presenting with ischemic stroke, providing to clinicians the available information in order to individualize the treatment. Full article
(This article belongs to the Special Issue Stroke in the Young)
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