Sepsis in a Changing Environmental and Technological Landscape

Dear Colleagues,

Sepsis is considered to be “a life-threatening organ dysfunction caused by a dysregulated host response to infection [1]“. While much has been learned about sepsis pathophysiology over the last 25–30 years, and treatment guidelines have been updated through successive Surviving Sepsis Campaigns, many questions remain. In this Special Issue of the International Journal of Environmental Research and Public Health, the objective is to consider how environmental factors and changing technology may be influencing the incidence, pathophysiology, progression, treatment, monitoring, and outcome of sepsis. Environmental changes and technological factors include a broad range of subjects, ranging from but not limited to issues around bacterial resistance and early antibiotic treatment, gene–environment interactions, the effects of pollution on sepsis susceptibility, and the non-invasive monitoring of patients, to the effects of intensive care unit design and the use of biomarkers and artificial intelligence in the management of sepsis patients.

1. Singer, M.; Deutschman, C.S.; Seymour, C.W.; Shankar-Hari, M.; Annane, D.; Bauer, M.; Bellomo, R.; Bernard, G.R.; Chiche, J.D.; Coopersmith, C.M., et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 2016, 315, 801–810.

Dr. Ryon M. Bateman
Guest Editor

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• Sepsis
• Environment
• Technology and pathophysiology