Asphyxia and Resuscitation in Neonates

A special issue of Healthcare (ISSN 2227-9032).

Deadline for manuscript submissions: closed (30 November 2019) | Viewed by 20977

Special Issue Editor


E-Mail Website1 Website2
Guest Editor
1. Department of Pediatrics, University of Alberta, Edmonton, AB T6G 2R3, Canada
2. Centre for the Studies of Asphyxia and Resuscitation, Royal Alexandra Hospital, Alberta Health Services, Edmonton, AB T5H 3V9, Canada
Interests: RETAIN to teach neonatal resuscitation; pulseless electrical activity in newborns; fetal to neonatal transition; neonatal and pediatric cardiopulmonary resuscitation; clinical trials
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Special Issue Information

Dear Colleagues,

Most newborn infants successfully make the transition from fetal to neonatal life without any help. An estimated 10–20% of newborns (13–26 million worldwide) need respiratory support, which remains the most critical step of neonatal resuscitation. Furthermore, 0.1% of term infants and up to 15% of preterm infants (2–3 million worldwide) need extensive resuscitation, defined as chest compression and 100% oxygen with or without epinephrine in the delivery room. Despite such care, approximately 1 million newborn die annually worldwide. Infants receiving extensive resuscitation in the delivery room have a high incidence of mortality (41%) and short-term neurologic morbidity (e.g., 57% hypoxic-ischemic encephalopathy and seizures). A recent review of newborns who received prolonged chest compression and epinephrine but had no signs of life at 10 minutes following birth noted 83% mortality, with 93% of survivors suffering moderate-to-severe disability. The poor prognosis associated with receiving chest compression alone or with medications in the delivery room raises questions as to whether improved cardiopulmonary resuscitation methods specifically tailored to the newborn could improve outcomes. The inability to predict which newborns need cardiopulmonary resuscitation and the infrequent use of cardiopulmonary resuscitation in the delivery room have limited neonatologists’ ability to perform rigorous clinical studies to determine the best methodologies for neonatal chest compression.

The Special Issue “Asphyxia and Resuscitation in Neonates” aims to highlight all aspects of neonatal resuscitation and how outcomes for newborns could be improved.

Dr. Georg M. Schmölzer
Guest Editor

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Keywords

  • Delivery room
  • Newborn
  • Asphyxia
  • Resuscitation

Published Papers (3 papers)

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Review

10 pages, 600 KiB  
Review
Heart Rate Assessment during Neonatal Resuscitation
by Peter A. Johnson and Georg M. Schmölzer
Healthcare 2020, 8(1), 43; https://doi.org/10.3390/healthcare8010043 - 23 Feb 2020
Cited by 21 | Viewed by 12361
Abstract
Approximately 10% of newborn infants require some form of respiratory support to successfully complete the fetal-to-neonatal transition. Heart rate (HR) determination is essential at birth to assess a newborn’s wellbeing. Not only is it the most sensitive indicator to guide interventions during neonatal [...] Read more.
Approximately 10% of newborn infants require some form of respiratory support to successfully complete the fetal-to-neonatal transition. Heart rate (HR) determination is essential at birth to assess a newborn’s wellbeing. Not only is it the most sensitive indicator to guide interventions during neonatal resuscitation, it is also valuable for assessing the infant’s clinical status. As such, HR assessment is a key step at birth and throughout resuscitation, according to recommendations by the Neonatal Resuscitation Program algorithm. It is essential that HR is accurate, reliable, and fast to ensure interventions are delivered without delay and not prolonged. Ineffective HR assessment significantly increases the risk of hypoxic injury and infant mortality. The aims of this review are to summarize current practice, recommended techniques, novel technologies, and considerations for HR assessment during neonatal resuscitation at birth. Full article
(This article belongs to the Special Issue Asphyxia and Resuscitation in Neonates)
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10 pages, 221 KiB  
Review
Chest Compression in Neonatal Cardiac Arrest: Cerebral Blood Flow Measurements in Experimental Models
by Anne Lee Solevåg, Po-Yin Cheung and Georg M. Schmölzer
Healthcare 2020, 8(1), 17; https://doi.org/10.3390/healthcare8010017 - 10 Jan 2020
Cited by 1 | Viewed by 3141
Abstract
The main aim of this paper was to provide an overview of studies that measured cerebral blood flow (CBF), directly or indirectly, during chest compression (CC) in neonatal animals. Our main research question was: how did different ways of performing CC influence CBF. [...] Read more.
The main aim of this paper was to provide an overview of studies that measured cerebral blood flow (CBF), directly or indirectly, during chest compression (CC) in neonatal animals. Our main research question was: how did different ways of performing CC influence CBF. We also aimed to discuss strengths and limitations of different methods for measuring CBF. Based on a search in Medline Ovid, we identified three studies in piglets that investigated different CC:ventilation (C:V) ratios, as well as three piglet studies investigating continuous CC with asynchronous ventilation. CBF was measured indirectly in all studies by means of carotid artery (CA) flow and regional cerebral oxygenation (rcSO2). The CA provides flow to the brain, but also to extracerebral structures. The relative sizes of the internal and external carotid arteries and their flow distributions are species-dependent. rcSO2 is a non-invasive continuous measure, but does not only reflect CBF, but also cerebral blood volume and the metabolic rate of oxygen in the brain. Continuous CC with asynchronous ventilation at a CC rate of 120/min, and combining CC with a sustained inflation (four studies in piglets and one in lambs) provided a faster CBF recovery compared with the standard 3:1 C:V approach. Full article
(This article belongs to the Special Issue Asphyxia and Resuscitation in Neonates)
10 pages, 931 KiB  
Review
The RETAIN Simulation-Based Serious Game—A Review of the Literature
by Simran K. Ghoman and Georg M. Schmölzer
Healthcare 2020, 8(1), 3; https://doi.org/10.3390/healthcare8010003 - 22 Dec 2019
Cited by 16 | Viewed by 4950
Abstract
Background: Each year, over 13 million babies worldwide need help to breathe at birth. While guidelines recommend the Neonatal Resuscitation Program course, medical errors remain common. Frequent simulation training and assessment is needed to address this competence gap; however, alternative approaches are needed [...] Read more.
Background: Each year, over 13 million babies worldwide need help to breathe at birth. While guidelines recommend the Neonatal Resuscitation Program course, medical errors remain common. Frequent simulation training and assessment is needed to address this competence gap; however, alternative approaches are needed to overcome barriers to access. The RETAIN (REsuscitation TrAINing) simulation-based serious game (Retain Labs Medical Inc., Edmonton, AB, Canada) may provide a solution to supplement traditional training. This paper aims to review the available evidence about RETAIN for improving neonatal resuscitation education. Method: Literature searches of PubMed, Google Scholar, Cochrane Central Register of Controlled Trials, CINAHL, Web of Science, and EMBASE databases were performed to identify studies examining the RETAIN serious game for neonatal resuscitation training. All of the studies describing the RETAIN board game and computer game were included. Results: Three papers and one conference proceeding were identified. Two studies described the RETAIN board game, and two studies described the RETAIN computer game. RETAIN was reported as usable and clinically relevant. RETAIN also improved knowledge of neonatal resuscitation by 12% and functioned as a summative assessment. Further, performance on RETAIN was moderated by players’ self-reported mindset. Conclusion: RETAIN can be used for the training and assessment of experienced neonatal resuscitation providers. Further studies are needed to understand the effectiveness of RETAIN to (i) improve other cognitive and non-cognitive skills, (ii) in diverse populations of neonatal resuscitation providers, (iii) in comparison to current standard training approaches, and (iv) in improving clinical outcomes in the delivery room. Full article
(This article belongs to the Special Issue Asphyxia and Resuscitation in Neonates)
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