Application of Artificial Intelligence in the Diagnosis, Treatment and Management of Diseases

A special issue of Healthcare (ISSN 2227-9032). This special issue belongs to the section "Artificial Intelligence in Medicine".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 1484

Special Issue Editors


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Tecnológico Nacional de México/ I. T. Orizaba, Orizaba 94320, Mexico
Interests: artificial intelligence; knowledge acquisition; semantic web; linked open data; big data
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Tecnológico Nacional de México/ I. T. Orizaba, Orizaba 94320, Mexico
Interests: big data; Internet of Things; knowledge management; software engineering; artificial intelligence
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Centro de Investigación en Matemáticas (CIMAT), Zacatecas 98160, Mexico
Interests: software engineering; quality; IT security; software process improvement
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Artificial Intelligence (AI) has evolved to offer great possibilities for improving the health of millions of people worldwide. Today, AI can be used to improve the speed and accuracy of diagnosis and early disease detection; facilitate clinical care; strengthen health research and drug development; and support various public health interventions, such as morbidity surveillance, outbreak response, and health systems management. AI also enables self-management of health, i.e., patients having greater control over their healthcare and a better understanding of their evolving needs. In addition, AI could facilitate access to health services in resource-poor countries and rural communities, where patients often have difficulty accessing health workers or medical staff.

One of the priorities of the World Health Organization is to highlight the need for accessible, affordable, and quality healthcare for everyone everywhere. Hence, the e-health services of the future that incorporate AI become vitally important, because, in addition to supporting specialists in healthcare, they will comprehensively include services for prevention, diagnosis, and follow-up of medical treatments. This will help to save lives, anticipate diseases, and optimize costs. Finally, although the global pandemic accelerated many digital initiatives to improve daily life, it also left many health systems with digital deficiencies in chaos, mainly in developing countries; thus, it is important to ensure that the global health sector has the necessary maturity for AI-based digital advances that will produce an exponential increase in the application of digital solutions in healthcare.

This Special Issue aims to collect and consolidate innovative and high-quality research contributions related to Artificial Intelligence in healthcare across different disciplines and its challenges, such as the personalized diagnosis, treatment, and management of diseases. AI in medical imaging and video has improved the efficiency of clinical trials; enhanced the early detection of disease; supported the diagnosis, treatment, and management and f-management of various diseases; improved clinical decision support, telehealth, and healthcare informatics systems; and optimized the generation of clinical expedients, among others.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Chatbots applied to mental health support, symptom assessment, patient triage, health education, medication management, and supporting telehealth services.
  • Computer vision applied to medical imaging for the precise localization, segmentation, and sizing of tumors, eyes, and skin and bone diseases, among others.
  • Data mining applied to predictive analytics, early detection, diagnosis, and forecasting of diseases.
  • Deep learning models to audit prescriptions vs. patient health records to identify and correct possible diagnostic errors or errors in prescription.
  • Deep learning techniques applied to the detection and diagnosis of diseases through the analysis of medical image data to acquire information for treatment planning and monitoring disease progression.
  • Expert medical systems to improve patient care by providing recommendations for medical decision making.
  • Fuzzy logic applicable for developing knowledge-based systems in medicine for tasks such as the interpretation of sets of medical findings and the diagnosis of diseases.
  • Machine learning applications for predictive analysis of disease outbreaks in a population and pattern detection for early disease diagnosis.
  • Natural Language Processing applied to personalized patient care and to obtaining medical information from free text for relevant medical treatments.
  • Robotics applied to surgical treatments, including minimally invasive surgeries, orthopedic surgeries, and rehabilitation.

We look forward to receiving insightful contributions.

Prof. Dr. José Luis Sánchez-Cervantes
Prof. Dr. Giner Alor-Hernández
Dr. Jezreel Mejía-Miranda
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Healthcare is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • artificial intelligence
  • deep learning
  • e-health
  • intelligent systems
  • m-health
  • machine learning
  • smart health
  • vision transformer architectures
  • data mining
  • fuzzy logic
  • natural language processing
  • robotics
  • expert systems

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Published Papers (1 paper)

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15 pages, 3491 KiB  
Article
Generative Artificial Intelligence Models in Clinical Infectious Disease Consultations: A Cross-Sectional Analysis Among Specialists and Resident Trainees
by Edwin Kwan-Yeung Chiu, Siddharth Sridhar, Samson Sai-Yin Wong, Anthony Raymond Tam, Ming-Hong Choi, Alicia Wing-Tung Lau, Wai-Ching Wong, Kelvin Hei-Yeung Chiu, Yuey-Zhun Ng, Kwok-Yung Yuen and Tom Wai-Hin Chung
Healthcare 2025, 13(7), 744; https://doi.org/10.3390/healthcare13070744 - 27 Mar 2025
Viewed by 333
Abstract
Background/Objectives: The potential of generative artificial intelligence (GenAI) to augment clinical consultation services in clinical microbiology and infectious diseases (ID) is being evaluated. Methods: This cross-sectional study evaluated the performance of four GenAI chatbots (GPT-4.0, a Custom Chatbot based on GPT-4.0, Gemini Pro, [...] Read more.
Background/Objectives: The potential of generative artificial intelligence (GenAI) to augment clinical consultation services in clinical microbiology and infectious diseases (ID) is being evaluated. Methods: This cross-sectional study evaluated the performance of four GenAI chatbots (GPT-4.0, a Custom Chatbot based on GPT-4.0, Gemini Pro, and Claude 2) by analysing 40 unique clinical scenarios. Six specialists and resident trainees from clinical microbiology or ID units conducted randomised, blinded evaluations across factual consistency, comprehensiveness, coherence, and medical harmfulness. Results: Analysis showed that GPT-4.0 achieved significantly higher composite scores compared to Gemini Pro (p = 0.001) and Claude 2 (p = 0.006). GPT-4.0 outperformed Gemini Pro and Claude 2 in factual consistency (Gemini Pro, p = 0.02; Claude 2, p = 0.02), comprehensiveness (Gemini Pro, p = 0.04; Claude 2, p = 0.03), and the absence of medical harm (Gemini Pro, p = 0.02; Claude 2, p = 0.04). Within-group comparisons showed that specialists consistently awarded higher ratings than resident trainees across all assessed domains (p < 0.001) and overall composite scores (p < 0.001). Specialists were five times more likely to consider responses as “harmless”. Overall, fewer than two-fifths of AI-generated responses were deemed “harmless”. Post hoc analysis revealed that specialists may inadvertently disregard conflicting or inaccurate information in their assessments. Conclusions: Clinical experience and domain expertise of individual clinicians significantly shaped the interpretation of AI-generated responses. In our analysis, we have demonstrated disconcerting human vulnerabilities in safeguarding against potentially harmful outputs, which seemed to be most apparent among experienced specialists. At the current stage, none of the tested AI models should be considered safe for direct clinical deployment in the absence of human supervision. Full article
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