Social Functioning Determinants of the Clinical Course and Outcomes of Autism Spectrum Disorder

A special issue of Healthcare (ISSN 2227-9032).

Deadline for manuscript submissions: 30 April 2026 | Viewed by 813

Special Issue Editors


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Guest Editor
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA
Interests: autism; social functioning; heterogeneity; precision medicine

E-Mail Website
Guest Editor
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA
Interests: autism spectrum disorders; affective neuroscience; developmental cognitive neuroscience

Special Issue Information

Dear Colleagues,

Autism is a highly prevalent neurodevelopmental condition that can have profound health implications and associated costs. These challenges are significant not only for individuals with autism but also for their families and the broader healthcare system. Consequently, there is a critical need to characterize the determinants of the clinical course of autism and the outcomes that impact this population so that they can be factored into treatment planning and intervention strategies to optimize care and resource allocation. One pertinent determinant is the variability in different aspects of social functioning, including social communication skills, social understanding, and motivation to engage socially. While alterations across these domains form part of the diagnostic criteria for autism, individuals with autism differ widely with respect to their manifestation of these characteristics. This heterogeneity can lead to diverse clinical outcomes, making it essential to fully understand the extent and clinical impact of differences in these socio-emotional domains.

This Special Issue aims to offer novel insights into how individual differences in social functioning—such as social communication, understanding, and motivation—act as determinants of clinical outcomes in autism. Original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: characterizing clinically meaningful social functioning subtypes, exploring developmental trajectories, analyzing social functioning in relation to co-occurring conditions and well-being, predicting intervention response, evaluating familial and environmental influences, and validating assessment tools.

We look forward to receiving your contributions.

Dr. Lacey Chetcuti
Dr. Mirko Uljarevic
Guest Editors

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Keywords

  • autism
  • social functioning
  • social-communication
  • social understanding
  • social motivation
  • heterogeneity
  • clinical prediction

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Published Papers (1 paper)

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Review

19 pages, 872 KB  
Review
Processes Associated with the Development of Depression in Autistic Individuals: A Narrative Review
by Yaerin H. Wallenberger, Mirko Uljarevic, Lacey Chetcuti and Samuel P. Putnam
Healthcare 2025, 13(23), 3112; https://doi.org/10.3390/healthcare13233112 - 28 Nov 2025
Viewed by 306
Abstract
Autistic individuals are disproportionately likely to experience mental health challenges during their lifetime, with depressive disorders being particularly common. High rates of depression among autistic individuals are a particular matter of clinical and policy concern, given the well-established links between depression and a [...] Read more.
Autistic individuals are disproportionately likely to experience mental health challenges during their lifetime, with depressive disorders being particularly common. High rates of depression among autistic individuals are a particular matter of clinical and policy concern, given the well-established links between depression and a range of negative outcomes, including suicidality. By proposing a novel integrative model, we aim to synthesize existing knowledge and prompt innovation in previously under-explored areas. In this narrative review, we first briefly discuss the prevalence of depression in autism, potential differences in how depression may present in autistic vs. non-autistic populations, and conceptual considerations for research on co-occurring autism and mental health challenges. We then provide a summary of cognitive, developmental, and clinical factors that have been identified through previous studies as important contributors to elevated rates and severity of depression in autistic individuals. Several, often closely interrelated, factors may affect the development and maintenance of depression in this population, including core autism features as well as cognitive and emotional experiences that are common in autistic individuals but not part of the diagnostic criteria for autism. Further, we propose a conceptual integration of the noted factors, specifying potential patterns of their interrelatedness. Finally, we put forward conceptual and empirical strategies for formally testing and refining our proposed model, and describe its implications for research, clinical practice, and societal reform. Full article
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