Special Issue "Genetics of Intellectual Disability"

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".

Deadline for manuscript submissions: 22 November 2019.

Special Issue Editor

Guest Editor
Prof. Paul Dawson Website E-Mail
University of Queensland, Brisbane, Australia

Special Issue Information

Dear Colleagues,

Intellectual disability and its co-morbidities present a major social and economic impact on families and society. The etiology of intellectual disability is complex, involving both genetic and environmental risk factors. In most cases of intellectual disability, diagnosis is based on clinical phenotypes, which limits the clinician’s decisions on prognosis and therapeutic treatment. Accordingly, there is an urgent need to generate a molecular diagnostic and antenatal screening tool for intellectual disability. In recent years, the emergence of rapid and cost-effective DNA sequencing has provided insights into the genetics of intellectual disability.

This Special Issue provides an update on the molecular defects that underlie the etiology of intellectual disability, allowing the opportunity to sub-classify the disorder, provide better informed advice about prognosis, and seek therapeutic approaches to treatment.

Prof. Paul Dawson
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • genetics
  • intellectual disability
  • etiology
  • neurodevelopment
  • syndromic
  • non-syndromic
  • disorder
  • gene network
  • neurotransmission

Published Papers (1 paper)

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Research

Open AccessArticle
Reconstruction and Analysis of Gene Networks of Human Neurotransmitter Systems Reveal Genes with Contentious Manifestation for Anxiety, Depression, and Intellectual Disabilities
Genes 2019, 10(9), 699; https://doi.org/10.3390/genes10090699 - 11 Sep 2019
Abstract
Background: The study of the biological basis of anxiety, depression, and intellectual disabilities in humans is one of the most actual problems of modern neurophysiology. Of particular interest is the study of complex interactions between molecular genetic factors, electrophysiological properties of the nervous [...] Read more.
Background: The study of the biological basis of anxiety, depression, and intellectual disabilities in humans is one of the most actual problems of modern neurophysiology. Of particular interest is the study of complex interactions between molecular genetic factors, electrophysiological properties of the nervous system, and the behavioral characteristics of people. The neurobiological understanding of neuropsychiatric disorders requires not only the identification of genes that play a role in the molecular mechanisms of the occurrence and course of diseases, but also the understanding of complex interactions that occur between these genes. A systematic study of such interactions obviously contributes to the development of new methods of diagnosis, prevention, and treatment of disorders, as the orientation to allele variants of individual loci is not reliable enough, because the literature describes a number of genes, the same alleles of which can be associated with different, sometimes extremely different variants of phenotypic traits, depending on the genetic background, of their carriers, habitat, and other factors. Results: In our study, we have reconstructed a series of gene networks (in the form of protein–protein interactions networks, as well as networks of transcription regulation) to build a model of the influence of complex interactions of environmental factors and genetic risk factors for intellectual disability, depression, and other disorders in human behavior. Conclusion: A list of candidate genes whose expression is presumably associated with environmental factors and has potentially contentious manifestation for behavioral and neurological traits is identified for further experimental verification. Full article
(This article belongs to the Special Issue Genetics of Intellectual Disability)
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