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Special Issue "RNA Interference 2016"
Deadline for manuscript submissions: closed (30 September 2016).
RNA interference (RNAi) is a conserved gene-regulation mechanism in all eukaryotic cells, where micro-RNA (miRNA), small interfering RNA (siRNA), and small hairpin RNA (shRNA) interact with mRNAs in a sequence-specific way and cause the cleavage or translational blockage of the gene. Since its discovery in 1996, it has been widely used as a powerful tool for gene function study in many biology laboratories worldwide. In addition, because the blockage is very specific and at the transcriptional level, RNAi-mediated gene silencing (RNAi therapy) is believed to hold great promise for effectively treating many diseases. For example, RNAi has been proven to be an effective means in gene therapy for viral infections, genetic disorders and cancers. As the advance of drug delivery systems especially with the advanced nanotechnology, siRNA delivery has been greatly proceeded and exciting results have been achieved, which makes RNAi therapy much closer to clinical application. Beside RNAi therapy, another area under active investigation is the relationship between RNAi pathway and host immune system; that is RNAi not only involves in innate immunity but also adaptive immunity. A better understanding of this relationship and combination of gene silencing with induced immunity will lead to more effective and safe therapies for cancer or other diseases.
Dr. Wenyi Gu
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- RNA interference
- Gene therapy
- Gene silencing
- miRNA /therapy
- Drug/siRNA delivery
- RNAi and immunity
- miRNA and immunity