Genetic Research on Cerebrovascular Disease and Stroke
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: 25 September 2025 | Viewed by 124
Special Issue Editor
Special Issue Information
Dear Colleagues,
Stroke, both ischemic and hemorrhagic, represents a growing societal challenge due to its significant impact on patients, caregivers, and healthcare systems. The disease is the end result of complex interactions between genetic and environmental factors. Recent advances in genetic research shed light on the intricate regulatory mechanisms that contribute to the development and consequences of such condition. Up to 50% of stroke risk is unexplained by conventional risk factors, with a large part of this unexplained risk thought to be the result of genetic factors. Recent advances in the field of gene identification—notably, genome-wide association studies (GWAs)—have resulted in the tremendous growth of genetic variants being related to disease phenotypes, especially with regard to brain ischemia. Likewise, although monogenic disorders account for about 1% to 5% of all strokes, their diagnosis is important for correct management, including genetic counseling, preventive measures, and therapeutic decisions, and discovering their pathogenetic mechanism could provide insight into the mechanisms underlying multifactorial ischemic stroke. A large number of single-gene disorders have been described so far, as well-known causes of stroke. Despite these achievements, challenges remain in translating genetic and genomic discoveries into clinical practice due to disease heterogeneity and the complexity of stroke pathophysiology. Future integration of genetic technologies holds promise for transforming diagnostic and prognostic paradigms, offering hope for improved patient outcomes and precision medicine approaches.
This Special Issue aims to advance genetic and genomic research in stroke, highlighting studies that explore the underlying genetic and genomic mechanisms and their clinical implications. Our objective is to deepen insights into genetic predispositions, genetic markers, comparative genomics, genetic diversity, and the overall genetic and genomic mechanisms driving stroke.
Prof. Dr. Alessandro Pezzini
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- stroke
- genetics
- genomics
- risk factors
- outcome
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
