Chromosomal Instability in Cancer

Dear Colleagues,

Chromosomal instability (CIN) is a feature of some of the most aggressive cancers and has been linked to tumor progression and theurapeutic resistance. CIN is a driver of genetic heterogeneity, aneuploidy and somatic copy number change, and recent studies have revealed, in increasing detail, the complex ways in which CIN reshapes cancer genomes to produce more fit tumor genotypes. Further research promises to increase our mechanistic understanding of CIN, and provide insights into the vulnerabilities that would allow for the therapeutic targeting of CIN-high cancers.

In this Special Issue, we invite authors to share their latest findings and perspectives on chromosomal instability in cancer. We are particularly interested in submissions that explore the impact of CIN on genomic, epigenomic and phenotypic heterogeneity. We encourage contributions that leverage single-cell techniques to examine the genomic and phenotypic consequences of CIN. We are also interested in studies of the evolutionary dynamics in chromosomally unstable cancers, in addition to studies that link CIN with DNA repair deficiencies, replication stress, and mutational processes. We welcome both reviews and original articles exploring CIN in cancer.

Dr. Andrew McPherson
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• chromosomal instability
• aneuploidy
• copy number change
• evolution
• single cell
• chromothripsis
• mis-segregation