DNA and Chromosomal Lesions in Tumorigenesis
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 4129
Special Issue Editors
Interests: DNA damage; flavonoids; DNA repair; cytogenetics; radiobiology
Special Issues, Collections and Topics in MDPI journals
Interests: clinical oncology; pathology; tumorigenesis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
DNA and chromosomal lesions are one of the most important processes to initiate tumorigenesis. DNA damages including base damage, single strand breaks, double strand breaks, inter- and intra-strand crosslinks, and DNA–protein crosslinks can act as initiators. Chromosomal lesions including amplifications, deletions, inversions, translocations, and aneuploidy are often microscopically observable loss, gain or rearrangement of a particular or whole segment of a chromosome. These small or large lesions can cause alterations in oncogenes and tumor suppressor genes of somatic cells. These mutations occur spontaneously and via endogenous stress including ionizing radiation, ultraviolet light, oxidative stress, anticancer agents, and toxic mutagens.
This Special Issue will provide readers with information on "DNA and Chromosomal Lesions in Tumorigenesis". In particular, it will collect papers on the spontaneous and exogeneous stress altering genomic information and contributing transformation and tumorigenesis in in vitro cell cultures, in vivo animal experiments, and in human cancer patients. The mechanisms of generation of DNA and chromosomal lesions and the repair process are also topics of interest.
In this Special Issue, we expect to publish research manuscripts reporting computer software simulations, in vitro chemical reactions, and cellular and in vivo analyses. In addition, studies on novel methods to detect genomic alterations and translational research regarding experimental chemoprevention of tumorigenesis in cells and model animals are welcome. Therefore, this collection of interdisciplinary papers on DNA and chromosomal lesions in tumorigenesis will be a good reference for a broad range of readers, including modelers, chemists, biologists, and clinical researchers.
Prof. Takamitsu Kato
Prof. Mami Murakami
Guest Editors
Manuscript Submission Information
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Keywords
- DNA damage
- chromosomal aberrations
- initiators
- DNA repair
- mutations
- transformation
- tumorigenesis
- carcinogenesis
- chemoprevention
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