Genetic Regulation Mechanisms of Animal Reproduction

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Animal Genetics and Genomics".

Deadline for manuscript submissions: closed (20 January 2025) | Viewed by 1224

Special Issue Editors


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Guest Editor
College of Animal Science and Technology, Northeast Agricultural University, Harbin, China
Interests: animals; reproduction; molecular; regulation; genetics

E-Mail Website
Guest Editor Assistant
College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, China
Interests: animals; reproduction; molecular; genetics; toxicology

Special Issue Information

Dear Colleagues,

Reproduction is the continuation of life and ensures species diversity and stability. The regulation of animal reproduction is an important process in maintaining species’ reproduction and survival. Animal reproductive activity is regulated by the hypothalamic-pituitary-gonadal axis system and is influenced by many factors. In animals, differences in genetic basis and molecular regulation mechanisms are formed by natural selection in their long-term evolution. The essence of reproductive differences between different animals is that animals have different genetic backgrounds. Reproductive performance is one of many important factors affecting the efficiency of animal production. Animal reproductive traits are low-heritability traits controlled by multiple genes. Revealing the genetic basis and molecular regulation mechanism of reproduction can help us understand the deep causes of reproductive law, and even provide possibilities for breeding new agricultural animal varieties through molecular breeding methods and increasing the number of rare animals, which is of great significance for promoting agricultural animal production and for protecting wild animals. Therefore, this Special Issue will focus on the genetic mechanisms of reproductive traits in different animals. In addition, we will analyze the genetic mechanisms and molecular regulatory networks of animal reproductive traits at DNA, RNA, protein, and chromatin levels using a variety of methods, including transcriptomics, proteomics, metabolomics, monocytomics, and multiomics combined analysis.

Prof. Dr. He Huang
Guest Editor

Dr. Xue Wang
Guest Editor Assistant

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Keywords

  • animal reproduction
  • reproduction regulation
  • molecular regulation
  • reproductive performance
  • animal production
  • reproductive trait
  • reproductive law
  • genetic mechanisms

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Published Papers (1 paper)

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Research

12 pages, 3585 KiB  
Article
Melatonin Improves H2O2-Induced Oxidative Stress in Sertoli Cells Through Nrf2-Keap1 Signaling Pathway
by Ying Tang, Ziming Wang, Yanru Chen, Junying Wang, Hongzhan Wang, Bo Li, Bojing Liu and Peng Zheng
Genes 2024, 15(12), 1544; https://doi.org/10.3390/genes15121544 - 28 Nov 2024
Viewed by 926
Abstract
Background: Oxidative stress in the testicles of male livestock can cause reduced fertility. Melatonin is a natural product with antioxidant effects, but its specific antioxidant mechanism is still unclear. This study used calf testicular Sertoli cells as materials to explore the mechanism [...] Read more.
Background: Oxidative stress in the testicles of male livestock can cause reduced fertility. Melatonin is a natural product with antioxidant effects, but its specific antioxidant mechanism is still unclear. This study used calf testicular Sertoli cells as materials to explore the mechanism by which melatonin alleviates the oxidative stress of Sertoli cells, laying a foundation for improving the fertility of bulls. Methods: The optimal treatment concentrations of H2O2 and melatonin (MLT) were screened out using a CCK8 kit and MDA kit. Then, the cells were divided into four groups for treatment: control group, H2O2 treatment group, MLT treatment group, and H2O2 and MLT co-treatment group, then the MDA, ROS, GSH, and SOD contents were detected. Real-time quantitative PCR analysis and Western blot analysis were used to detect genes and proteins related to the Nrf2-Keap1 pathway. Immunofluorescence staining was used to analyze changes in Nrf2. Results: Research results show that the MDA content of cells in the group treated with H2O2 and MLT combined was significantly lower than that in the group treated with H2O2 alone, but there was no difference from the control group. Compared with the control group, the ROS level of cells in the H2O2-treated group significantly increased, and the content of GSH and SOD significantly decreased. Compared with the H2O2-treated group, the ROS level of cells in the H2O2 and MLT co-treated group significantly decreased, and the content of GSH and SOD increased significantly, but no difference from the control group. Similarly, MTL can alleviate the changes in cellular Nrf2, Keap1, HO-1, and NQO1 expression caused by H2O2. Conclusions: Melatonin activates the Nrf2-Keap1 signaling pathway in Sertoli cells, elevating the expression of HO-1 and NQO1, and thereby exerting its antioxidant capabilities. Full article
(This article belongs to the Special Issue Genetic Regulation Mechanisms of Animal Reproduction)
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