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The Canadian Epigenetics, Environment and Health Research Consortium Network is organizing the 4th annual symposium on “Mechanisms of Disease” to be held from 26-29 November 2017 in Whistler, British Columbia. This symposium is intended to bring together a critical mass of epigenetics researchers, along with key international leaders in the field, to engage in cross-disciplinary dialogue on recent advancements in the field of epigenomics with a focus on the impact of epigenetic mechanisms in human disease.