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Endocrines
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Feature Papers in Endocrines 2025
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Feature Papers in Endocrines 2025

A special issue of Endocrines (ISSN 2673-396X).

Deadline for manuscript submissions: 20 December 2025 | Viewed by 977

Special Issue Editors

Prof. Dr. Antonio Brunetti

E-Mail Website
Guest Editor
Department of Health Sciences, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, Italy
Interests: pathophysiology of insulin action and insulin signaling; molecular genetics of type 2 diabetes and severe insulin resistance syndromes; gestational diabetes mellitus; pharmacogenetics of type 2 diabetes; obesity, inflammation and cancer; transcriptional regulation of glucose metabolism; mechanisms of gene regulation and transcription networks; pituitary and thyroid tumors; animal models of insulin resistance and type 2 diabetes; diagnostic and prognostic biomarkers and therapeutic targets in diabetes
Special Issues, Collections and Topics in MDPI journals
Dr. Maria Mirabelli

E-Mail Website
Guest Editor
Department of Health Sciences, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, Italy
Interests: diabetes; pharmacological therapies for type 2 diabetes; gestational diabetes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Endocrinology is a medical specialty dedicated to understanding the endocrine system, which regulates the release and function of hormones, growth factors, neurotransmitters, and other signaling molecules in the human body. These elements are critical for maintaining human health, and many diseases are either influenced by or result in hormonal imbalances. Conditions such as obesity, insulin resistance, metabolic syndrome, diabetes mellitus, thyroid dysfunction, osteoporosis, growth hormone disorders, and infertility are just a few examples. In addition to their pathophysiological roles, hormones, growth factors, neurotransmitters, and other signaling molecules can serve as disease biomarkers or potential therapeutic targets.

This Special Issue aims to collect high-quality, open-access articles submitted by editorial board members and leading experts invited by the editorial office and the Editor-in-Chief. Both original research papers and comprehensive review articles are welcome, provided they offer in-depth analyses and detailed summaries of the authors’ work. Contributions should focus on the molecular mechanisms and functions of hormones, the discovery of biomarkers, or the exploration of therapeutic strategies within the field of endocrinology.

Prof. Dr. Antonio Brunetti
Dr. Maria Mirabelli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Endocrines is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obesity, diabetes mellitus, and metabolic syndrome
  • lipid metabolism and cardiovascular implications
  • adrenal disorders and electrolyte balance
  • thyroid endocrinology
  • parathyroid disorders, mineral metabolism, and bone functions
  • neuroendocrinology and pituitary disorders
  • endocrine oncology
  • andrology and male sexual function
  • female reproductive system and pregnancy endocrinology
  • exercise endocrinology
  • endocrine immunology, cytokines, and cell signaling
  • pediatric endocrinology and growth disorders

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  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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9 pages, 412 KiB  
Article
Euglycemic Hyperinsulinemia Lowers Blood Pressure and Impedes Microvascular Perfusion More Effectively in Persons with Cardio-Metabolic Disease
by Zhenqi Liu, Linda A. Jahn and Eugene J. Barrett
Endocrines 2025, 6(3), 36; https://doi.org/10.3390/endocrines6030036 - 24 Jul 2025
Viewed by 253
Abstract
In healthy humans, insulin at physiological concentrations exerts acute vasodilatory actions on both resistance and terminal arterioles, leading, respectively, to increased total blood flow and the microvascular network volume being perfused. The process of increasing capillary network volume is frequently referred to as [...] Read more.
In healthy humans, insulin at physiological concentrations exerts acute vasodilatory actions on both resistance and terminal arterioles, leading, respectively, to increased total blood flow and the microvascular network volume being perfused. The process of increasing capillary network volume is frequently referred to as “capillary recruitment”. Together these two vascular actions of insulin enhance the delivery of oxygen, nutrients, and insulin itself to tissues. Both processes are diminished by insulin resistance. Here we examined interactions between insulin’s acute (within 2 h) actions on blood pressure (both central and peripheral) and on capillary recruitment in healthy controls and in four distinct groups of people with heightened cardio-metabolic disease (CMD) risk: individuals with obesity, metabolic syndrome, and type 1 or type 2 diabetes. Insulin increased microvascular blood volume (MBV) more effectively in controls than in each of the four CMD risk groups (p < 0.001). Conversely, insulin lowered both central and peripheral systolic pressure (p < 0.05 or less) in each of the CMD risk groups but not in the controls. The insulin-induced blood pressure decrements were greater in the metabolic syndrome, type 2 diabetes, and obesity groups (p < 0.05 or less) than in the controls. The greater blood pressure declines likely reflect decreased sympathetic baroreceptor reflex tone. These effects on blood pressure combined with the diminished dilation of terminal arterioles due to microvascular insulin resistance in the CMD risk subjects led to decreased distal microvascular perfusion as evidenced by changes in MBV. These findings highlight the complex interplay between insulin’s actions on resistance and terminal arterioles in individuals with a high CMD risk, underscoring the importance of addressing microvascular dysfunction in these conditions. Full article
(This article belongs to the Special Issue Feature Papers in Endocrines 2025)
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Review

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10 pages, 239 KiB  
Review
Time in Tight Range: A New Frontier in Glycemic Control or Just a Tighter Time in Range? A Narrative Review
by Gonzalo Diaz Soto, Pablo Fernández Velasco and Pilar Bahillo Curieses
Endocrines 2025, 6(3), 34; https://doi.org/10.3390/endocrines6030034 - 9 Jul 2025
Viewed by 316
Abstract
Background/Objectives: Continuous glucose monitoring (CGM) has transformed diabetes management, with time in range (TIR) emerging as a key glycemic metric. However, TIR lacks sensitivity to glycemic variability, leading to the introduction of time in tight range (TiTR), which defines a narrower range (70–140 [...] Read more.
Background/Objectives: Continuous glucose monitoring (CGM) has transformed diabetes management, with time in range (TIR) emerging as a key glycemic metric. However, TIR lacks sensitivity to glycemic variability, leading to the introduction of time in tight range (TiTR), which defines a narrower range (70–140 mg/dL). This review synthesizes current evidence on TiTR’s clinical relevance and its potential to predict complications. Methods: A literature search was conducted, primarily using PubMed as the main database, to identify studies that specifically evaluate TiTR and its clinical implications, published until February 2025. Results: Preliminary data indicate that a 10% increase in TiTR is associated with a 23.8% reduction in microvascular complications. While TiTR aligns more closely with physiological glucose control, standardized targets remain undefined. Conclusions: This study provides clinicians with insights into optimizing glycemic control beyond traditional metrics. The correlation of TiTR with other glycemic markers and its association with diabetes-related complications suggest that TiTR can complement traditional measures to provide a more comprehensive assessment of glycemic status. From a clinical perspective, incorporating TiTR into routine practice may help personalize treatment strategies, improve risk stratification, and support more precise therapeutic decisions, particularly in patients using continuous glucose monitoring (CGM). Future research should refine TiTR thresholds and evaluate its integration into diabetes management, particularly in populations using advanced technologies. Full article
(This article belongs to the Special Issue Feature Papers in Endocrines 2025)
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