Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
DNA
Special Issues
Epigenetics and Environmental Exposures
share announcement

Epigenetics and Environmental Exposures

A special issue of DNA (ISSN 2673-8856).

Deadline for manuscript submissions: 20 September 2025 | Viewed by 3101

Special Issue Editors

Dr. Benoît Miotto

E-Mail Website
Guest Editor
Team Epigenetics, DNA replication and Cancer, Université de Paris, Institut Cochin, INSERM, F-75014 Paris, France
Interests: DNA replication; epigenetics; cancer
Dr. Tina Bianco-Miotto

E-Mail Website
Guest Editor
School of Agriculture, Food and Wine, Waite Research Institute, University of Adelaide, Adelaide, SA 5005, Australia
Interests: epigenetics; DNA methylation; development

Special Issue Information

Dear Colleagues,

It is well known that our lifestyles, as well as our environment, have a pronounced effect on our organisms. Examples abound of how chemical compounds and xenobiotics present in food, water or the atmosphere are capable of altering epigenetic status and gene expression and thus impact human health. Studies have also shown how diet, anxiety, lack of sleep or a sedentary lifestyle can affect epigenetic status, gene expression and human health. More importantly, some studies have reported on the long-term effects of these exposures or effects linked to low-dose exposure.

Epigenetic modifications (e.g., DNA methylation, histone modifications, histone variants, non-coding RNAs) play a central role in regulating various essential cellular processes. These modifications are extremely sensitive to changes in cell metabolism or cell signalling induced by environmental signals. Characterizing the relationship between environmental exposures, these modifications and their functions is essential to better understand how environmental signals can be linked to disease or long-term effects.

In this Special Issue, we welcome review articles and original research studies exploring these aspects in vitro, in cellular and animal models as well as in human.

Dr. Benoît Miotto
Dr. Tina Bianco-Miotto
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. DNA is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • epigenetics
  • chemicals
  • histone marks and variants
  • DNA methylation
  • non-coding RNAs
  • diseases
  • chromatin organisation
  • low-dose and cocktail effects

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

9 pages, 459 KiB  
Article
Child Telomere Length at 11–12 Years of Age Is Not Associated with Pregnancy Complications
by Tina Bianco-Miotto, Sadia Hossain, Nahal Habibi, Dandara G. Haag and Jessica A. Grieger
DNA 2024, 4(2), 180-188; https://doi.org/10.3390/dna4020011 - 11 Jun 2024
Cited by 1 | Viewed by 1254
Abstract
Children born from pregnancy complications are at higher risk of chronic diseases in adulthood. Identifying which children born from a complicated pregnancy are likely to suffer from later chronic disease is important in order to intervene to prevent or delay the onset of [...] Read more.
Children born from pregnancy complications are at higher risk of chronic diseases in adulthood. Identifying which children born from a complicated pregnancy are likely to suffer from later chronic disease is important in order to intervene to prevent or delay the onset of disease. This study examined the associations between the major pregnancy complications (gestational diabetes, high blood pressure, small- and large for gestational age, and preterm birth) and child telomere length, a biomarker of chronic disease risk. This was a population-based longitudinal analysis using data from the Longitudinal Study of Australian Children. The primary outcome is telomere length, measured in 11–12-year-old children. Multivariable linear regression was used to estimate the association between pregnancy complications and child telomere length, adjusting for a range of a priori confounders. Data from 841 families were used. One in four pregnancies (27.1%) featured a pregnancy complication. In the adjusted analysis, there was no association between pregnancy complications and child telomere length (high blood pressure: mean difference (95% CI): 0.00 (−0.12, 0.12); gestational diabetes (0.05 (−0.10, 0.19)); small for gestational age (0.07 (−0.04, 0.19)); large for gestational age (−0.06 (−0.15, 0.03)); and preterm birth (−0.10 (−0.21, 0.01)). Our results do not support the notion that telomere length is shorter in children born to mothers after a pregnancy complication. Methodological considerations should be rigorous to improve the reproducibility of findings. Full article
(This article belongs to the Special Issue Epigenetics and Environmental Exposures)
►▼ Show Figures

Figure 1

Review

Jump to: Research

26 pages, 964 KiB  
Review
Genomic and Epigenomic Plasticity in the Hypoxic Environment
by Emanuele Cricchi, Alessio Bertozzo, Martina Minisini and Claudio Brancolini
DNA 2025, 5(2), 22; https://doi.org/10.3390/dna5020022 - 4 May 2025
Viewed by 229
Abstract
Our genome has evolved a complex network of information designed to precisely regulate gene transcription. Commonly known as cis-regulatory elements, they represent those parts of DNA that are highly sensitive to environmental changes in the form of associated multi-protein complexes. Oxygen levels are [...] Read more.
Our genome has evolved a complex network of information designed to precisely regulate gene transcription. Commonly known as cis-regulatory elements, they represent those parts of DNA that are highly sensitive to environmental changes in the form of associated multi-protein complexes. Oxygen levels are an important environmental factor influencing a range of cellular activities, including cell survival. To respond to changes in oxygen levels, cells have developed an efficient and precise system for regulating gene expression. Cis-regulatory elements are the key hubs of this response and control the activation of the transcriptional response to hypoxia. In this review, we will discuss the complex genomic and epigenomic structures that are modulated by oxygen and control the activity of cis-regulatory elements and the adaptations to variations in O2 availability. Full article
(This article belongs to the Special Issue Epigenetics and Environmental Exposures)
►▼ Show Figures

Graphical abstract

17 pages, 862 KiB  
Review
Chemical Versus Enzymatic Nucleic Acid Modifications and Genomic Stability
by Jonathan R. Cortez and Marie E. Migaud
DNA 2025, 5(2), 19; https://doi.org/10.3390/dna5020019 - 9 Apr 2025
Viewed by 485
Abstract
DNA damage and repair have been central themes in cellular biology research. Broadly, DNA damage is understood as modifications to canonical nucleotides that disrupt their function during transcription and replication. A deeper biochemical understanding of DNA damage is essential, as the genome governs [...] Read more.
DNA damage and repair have been central themes in cellular biology research. Broadly, DNA damage is understood as modifications to canonical nucleotides that disrupt their function during transcription and replication. A deeper biochemical understanding of DNA damage is essential, as the genome governs all cellular processes. We can classify DNA damage according to whether the modifications to the nucleic acid scaffold are chemically or enzymatically initiated. This distinction is important because chemical modifications are often irreversible, sometimes sparse, and difficult to detect or control spatially and replicate systematically. This can result in genomic damage or modifications to nucleotides in the nucleotide pool, which is less commonly studied. In contrast, enzymatic modifications are typically induced by the cell for specific purposes and are under strong regulatory control. Enzymatic DNA modifications also present a degree of sequence specificity and are often reversible. However, both types of DNA modifications contribute to cellular aging when poorly repaired and, as a result, remain incompletely understood. This review hopes to gather less studied mechanisms in nucleotide modifications and show research gaps in our current understanding of nucleotide biology. By examining the implications of these mechanisms on DNA modifications, in the nucleotide pool and genome, we may gain insights into innovative strategies for mitigating the effects of cellular aging. Full article
(This article belongs to the Special Issue Epigenetics and Environmental Exposures)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop