Gut Microbiome and Human Diseases II

Dear Colleague,

The gut microbiome is the most densely populated microbe within the human body. With various different species of microbes residing in the human gastrointestinal tract, host–microbial crosstalk contributes to the maintenance of a homeostatic relationship between the two parties. The gut microbiome exerts immunological and metabolic effects on the host. A disruption to the balanced relationship is involved in the pathogenesis of various diseases, with adverse shifts in the intestinal microbiome and their products through increased intestinal permeability and enhanced microbial translocation. Variable studies have confirmed the role of intestinal epithelial cell dysbiosis in the manifestation of metabolic syndrome and associated complications. The possible mechanism of action is microbial translocation due to increased intestinal permeability when bacteria and bacterial fragments leak into systemic circulation in a pro-inflammatory environment in various organs. Low-grade chronic systemic inflammation provokes immunological disturbances and contributes to the development of insulin resistance, diabetes mellitus, obesity-related complications, and even cancer.

This Special Issue, titled ‘Gut Microbiome and Human Diseases’, will aim to explore the current understanding of the role of the gut microbiome in the pathogenesis of various disorders, as well as research exploring how the gut microbiome can be manipulated with probiotics/prebiotics and antibiotics. We published several articles related to liver diseases, cardiovascular diseases, renal failure, and colon cancer in 2018 and 2019, which have successfully obtained many citations. In 2020, we would like to publish more articles as indicated in the keywords above.

Prof. Dr. Hiroshi Fukui
Guest Editor

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