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Dermatopathology
Special Issues
New Insights in Paediatric Dermatopathology 2025
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New Insights in Paediatric Dermatopathology 2025

A special issue of Dermatopathology (ISSN 2296-3529).

Deadline for manuscript submissions: 31 July 2026 | Viewed by 3307

Special Issue Editor

Dr. Sylvie Fraitag

E-Mail Website
Guest Editor
Department of Pathology, Necker Hospital for Sick Children, 75015 Paris, France
Interests: paediatrics; genodermatoses; pediatric inflammatory disorders; children cutaneous tumours; superficial paediatric soft tissue tumours; melanocytic proliferation in children
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Paediatric dermatopathology covers a wide range of disorders including genodermatoses, cutaneous and sub-cutaneous tumours, and inflammatory disorders.

Four years ago, we launched a first Special Issue dedicated to paediatric dermatopathology. It included topics such as paediatric panniculitis, auto-inflammatory disorders, paediatric melanoma, tuberous sclerosis complex, spindle-cell neoplasms, congenital cysts, and veinous malformations and attracted many readers. The success of this first Special Issue confirmed that dermatopathologists benefitted from having access to a comprehensive, up-to-date resource on key subjects in dermatopathology, and so we decided to publish another Special Issue in this field. This new Special Issue will endeavour to complement the first, with a wide range of topics in paediatric dermatopathology, focusing on conditions that have not been addressed up until now in this journal, such as paediatric vasculitis, paediatric cutaneous lymphoma, and other haematological disorders, paediatric tumours, desmosomal genodermatoses, keratinopathic ichthyoses, paediatric melanonychias, some disorders of mucous membranes in children, and paediatric cutaneous mucinoses.

We will again feature prestigious authors, both dermatopathologists and clinicians, who are experts in these fields. This Special Issue, like the first, will be aimed at dermatologists and pathologists who are interested in paediatric dermatopathology. We have no doubt that this new Special Issue will be as successful as its predecessor.

Dr. Sylvie Fraitag
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Dermatopathology is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pediatric dermatopathology
  • pediatric vascular tumors
  • childhood melanoma
  • auto-inflammatory disorders
  • nodules
  • neonates
  • infants
  • bullous eruption in infancy
  • cysts
  • histiocytosis
  • keratinization disorders
  • auto-inflammatory diseases

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  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
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Further information on MDPI's Special Issue policies can be found here.

Related Special Issues

Published Papers (3 papers)

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Research

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26 pages, 20174 KB  
Article
Desmosomal-Type Acantholysis—A New Histologic Pattern Related to Mutations of Genes for Desmosomal Proteins
by Dieter Metze, Kira Süßmuth, Clemens Metze, Vinzenz Oji and Heiko Traupe
Dermatopathology 2026, 13(2), 17; https://doi.org/10.3390/dermatopathology13020017 - 3 Apr 2026
Viewed by 633
Abstract
Desmosomes are specialized cell–cell junctions that play a crucial role in maintaining the structural integrity of both cornifying and non-cornifying epithelium. Disruption of desmosomal cohesion in autoimmune, infectious, and other diseases is typically associated with acantholysis, often leading to intraepidermal blisters and erosions. [...] Read more.
Desmosomes are specialized cell–cell junctions that play a crucial role in maintaining the structural integrity of both cornifying and non-cornifying epithelium. Disruption of desmosomal cohesion in autoimmune, infectious, and other diseases is typically associated with acantholysis, often leading to intraepidermal blisters and erosions. In recent decades, genetic mutations have been identified that impair desmosomal integrity to varying degrees, giving rise to a spectrum of genodermatoses. These conditions, which include palmoplantar keratoderma, epidermolysis bullosa, and ichthyoses, can range from mild to severe, with some forms being syndromic and life-threatening. We investigated dermatopathologic changes in patients with mutations in genes encoding desmosomal proteins seen in consultations at our genodermatoses unit. A series of cases, including keratosis palmoplantaris areata et striata (striated palmoplantar keratoderma type 1), Carvajal–Huerta syndrome, severe dermatitis–multiple allergies–metabolic wasting (SAM) syndrome, ectodermal dysplasia–skin fragility syndrome, and inflammatory peeling skin disease, was examined histologically and, when necessary, immunohistochemically. Findings from our cohort were compared with histopathological consultation cases from our dermatopathology laboratory and previously published cases in the literature. Through these observations, we defined a distinct form of acantholysis associated with desmosomal protein mutations, which we term “desmosomal-type acantholysis.” We outline the spectrum of this newly characterized pattern and highlight its differences from conventional forms of acantholysis. Furthermore, for the first time, we describe incidental cases where “desmosomal-type acantholysis” appears sporadically in solitary acanthoma and in association with a melanocytic nevus. Full article
(This article belongs to the Special Issue New Insights in Paediatric Dermatopathology 2025)
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Review

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19 pages, 15325 KB  
Review
Longitudinal Melanonychia in Children: Clinical and Histopathologic Features and Management with Literature Update
by Isabelle Moulonguet, Marie Caucanas and Sophie Goettmann
Dermatopathology 2026, 13(1), 13; https://doi.org/10.3390/dermatopathology13010013 - 23 Mar 2026
Viewed by 1399
Abstract
Longitudinal melanonychia (LM) results from the deposition of pigment in the nail plate due to increased melanocytic activity within the nail matrix. Recent publications on this topic have helped clarify the main clinical, histological, and evolutionary characteristics of pediatric LM and provide guidance [...] Read more.
Longitudinal melanonychia (LM) results from the deposition of pigment in the nail plate due to increased melanocytic activity within the nail matrix. Recent publications on this topic have helped clarify the main clinical, histological, and evolutionary characteristics of pediatric LM and provide guidance for its appropriate management. In this review, we will examine the literature on the subject. LM is far less common in children than in adults and is most often caused by benign nail matrix lesions. Pediatric LM has specific clinical and histopathologic features, and many of the clinical warning signs used in adults are not applicable to children. Pediatric lesions may show atypical cytologic and even architectural features yet still follow a benign clinical course. Spontaneous regression of LM is common in children, with fading and narrowing of the pigmented band, or even complete disappearance. The vast majority of pediatric LM cases can be managed conservatively with regular follow-up, including clinical photography and onychoscopy. Full article
(This article belongs to the Special Issue New Insights in Paediatric Dermatopathology 2025)
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9 pages, 1164 KB  
Review
Genital Disorders in Children: What Does a Biopsy Bring?
by Francoise Plantier and Fiona Lewis
Dermatopathology 2026, 13(1), 12; https://doi.org/10.3390/dermatopathology13010012 - 23 Mar 2026
Viewed by 551
Abstract
Biopsies are only performed in less than 1% of all consultations dedicated to paediatric genital dermatology. The objectives of this paper are to review and clarify the histopathological features of the conditions most often biopsied: first, lichen sclerosus, which has a peak incidence [...] Read more.
Biopsies are only performed in less than 1% of all consultations dedicated to paediatric genital dermatology. The objectives of this paper are to review and clarify the histopathological features of the conditions most often biopsied: first, lichen sclerosus, which has a peak incidence in childhood and progresses over years; secondly, pigmented lesions, including atypical genital naevi and common naevi in the context of lichen sclerosus, both histologically differential diagnoses of melanoma, which probably does not present in childhood. And finally, Crohn’s disease, which is a cause of vulval oedema or genital ulceration. Full article
(This article belongs to the Special Issue New Insights in Paediatric Dermatopathology 2025)
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