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Dermato
Special Issues
Systemic Photoprotection: New Insights and Novel Approaches
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Systemic Photoprotection: New Insights and Novel Approaches

A special issue of Dermato (ISSN 2673-6179).

Deadline for manuscript submissions: 31 March 2026 | Viewed by 397

Special Issue Editors

Dr. Lara Camillo

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Guest Editor
Dermatology Laboratory, Department of Health Sciences (DiSS), Università del Piemonte Orientale (UPO), Via Solaroli, 28100 Novara, Italy
Interests: non-melanoma skin cancer; nicotinamide; oxidative stress; molecular biology
Prof. Dr. Paola Savoia

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Guest Editor
Dermatology Unit, Department of Health Sciences (DiSS), School of Medicine, Università del Piemonte Orientale (UPO), Via Solaroli 17, 28100 Novara, Italy
Interests: melanoma; non-melanoma skin cancer; photoaging; cutaneous lymphomas
Special Issues, Collections and Topics in MDPI journals
Dr. Elisa Zavattaro

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Guest Editor
Department of Health Science, University of Eastern Piedmont, 13100 Novara, Italy
Interests: non-melanoma skin cancer; field cancerization; organ transplant recipients; melanoma
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Ultraviolet (UV) radiation is a key contributor to skin damage, driving many of the visible signs of aging and a large proportion of skin cancers. While topical sunscreens remain fundamental to protecting the skin, there is growing recognition that systemic interventions—such as dietary supplements and pharmacological agents—can complement topical protection and provide whole-body defense against UV injury. Over the past decade, the concept of “photoprotection from within” has gained substantial traction, with a majority of dermatologists acknowledging the potential of oral photoprotectors in skin cancer prevention. This heightened interest underscores the expanding clinical and research focus on systemic photoprotection.

This Special Issue, “Systemic Photoprotection: New Insights and Novel Approaches”, brings together dermatologists, pharmacologists, and cosmetic scientists to address the latest scientific and clinical advancements in systemic photoprotection. Our objective is to illustrate how strategies extending beyond topical sunscreens—including dietary and pharmacological interventions—can bolster skin health, reduce the impact of photoaging, and aid in the management of photodermatoses.

We welcome original research articles, case series, and review papers that contribute to a deeper understanding of this rapidly evolving field. By showcasing high-caliber studies and innovative perspectives, this Special Issue aims to foster multidisciplinary collaboration and guide future research on preventing and mitigating UV-induced skin damage through systemic avenues.

Dr. Lara Camillo
Prof. Dr. Paola Savoia
Dr. Elisa Zavattaro
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Dermato is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • systemic photoprotection
  • UV-induced skin damage
  • skin cancer prevention
  • photoaging
  • dietary supplements
  • oral photoprotectors
  • nutricosmetics
  • antioxidants

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Published Papers (1 paper)

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Research

18 pages, 2202 KB  
Article
Modulation of Piceatannol Skin Diffusion by Spilanthol and UV Filters: Insights from the Strat-M™ Model
by Gisláine C. da Silva, Rodney A. F. Rodrigues and Carla B. G. Bottoli
Dermato 2025, 5(4), 19; https://doi.org/10.3390/dermato5040019 - 7 Oct 2025
Viewed by 97
Abstract
Background: currently, there is a growing trend toward multifunctional cosmetics, which combine several active ingredients in a single product to enhance efficacy and user convenience. As ingredients may influence one another, it is important to study the behavior of mixing multiple compounds in [...] Read more.
Background: currently, there is a growing trend toward multifunctional cosmetics, which combine several active ingredients in a single product to enhance efficacy and user convenience. As ingredients may influence one another, it is important to study the behavior of mixing multiple compounds in complex formulations, especially regarding their interaction with the skin. Piceatannol, for instance, is a naturally occurring stilbene recognized for its in vitro potent antioxidant, anti-inflammatory, and anti-aging activities, making it a promising candidate for dermocosmetic use in suncare. But despite its beneficial biological activities, its cutaneous permeation remains poorly understood, particularly when delivered from complex formulations containing multiple ingredients. Objectives: in this sense, this study aimed to evaluate the in vitro skin diffusion profile of piceatannol from a passion fruit seed extract (Pext) incorporated into a topical base (Bem) or an organic sunscreen emulsion (Oem), with or without a spilanthol-rich Acmella oleracea extract (Jext) used as a natural permeation enhancer. Methods: due to ethical and variability issues with human and animal skins, the Strat-M™ synthetic membrane was chosen as a standardized model for the in vitro skin permeation assays. Piceatannol localization within membrane layers was examined by confocal Raman microscopy (CRM), while compound identification in donor and receptor compartments was performed via UHPLC-DAD. Results: piceatannol from Bem was detected up to 140 µm from the Strat-M™ surface and exceeded 180 µm in depth when Jext and organic sunscreens were included in the formulation. Notably, formulations containing Jext and those based on Oem promoted enhanced accumulation in both the stratum corneum and deeper skin layers, suggesting an improved delivery potential in lipid-rich vehicles. Conclusions: even though some instability issues were observed, piceatannol penetration into Strat-M™ from the proposed formulations was confirmed, and the results provide a foundation for further research on its topical delivery, supporting the rational development of formulations capable of harnessing its demonstrated biological properties. Full article
(This article belongs to the Special Issue Systemic Photoprotection: New Insights and Novel Approaches)
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