Sleep–Wake Medicine

Dear Colleagues,

Despite the fact that the states of sleep are universally described throughout the animal kingdom, our understanding of their contributions to brain function and dysfunction remains limited. Amassing evidence reveals close interactions between the brain and the body in the circadian organization of sleep and its homeostasis. It is therefore not surprising that disorders of the brain and the body are often associated with pre-symptomatic sleep perturbations. The understanding of both the fundamental and pathophysiological mechanisms of sleep control has benefitted from technological advances used in experimental and clinical contexts; however, the questions of “Why do we sleep?”; “What are the functions of sleep?” and “Why doesn’t our brain sleep when we are resting?” remain unanswered.

Recent progress triggered several paradigm shifts such as “global-to-local sleep control”, “single-to-multiple sleep circuits” or “Hebbian-to-non-Hebbian information consolidation” that have opened new hypotheses on the origin, functions and representations of sleep in neuroscience, medicine and in society. For this Special Issue, we aim to assemble empirical papers, targeted reviews and opinion pieces that will showcase our current understanding of the pathological association between sleep and neurological or psychiatric disorders and possible pathophysiological mechanisms in both animal and human models.

All types of papers are encouraged (research papers, targeted reviews, meta-analyses and commentaries, interviews). Manuscripts can cover studies in animals and/or humans, as well as theoretical concepts. Behavioral and/or pharmacological studies are welcome, but should be placed within the broader sleep medicine context.

Prof. Dr. Antoine Adamantidis
Dr. Markus Schmidt
Prof. Dr. Claudio Bassetti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Clinical and Translational Neuroscience is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• sleep–wake medicine
• circadian rhythm
• REM sleep
• NREM sleep
• sleep disorders
• narcolepsy