Regulatory Network of Key Cardiac Transcription Factors during Heart Development
A special issue of Cardiogenetics (ISSN 2035-8148).
Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 323
Special Issue Editor
Special Issue Information
Dear Colleagues,
The heart is the earliest organ to form during embryonic development, and its correct morphogenesis is essential to the survival of the embryo. The heart arises from anterior lateral plate mesodermal progenitors which form almost all of the different cardiac cell types through processes conserved across multiple vertebrate species. These morphogenetic processes occur in a highly coordinated fashion and are governed by an intricate interplay of highly specific gene regulatory networks. Disruption of these processes leads to congenital heart defects, which make up a significant percentage of childhood birth defects. Additionally, congenital heart defects are also involved in several syndromic genetic defects, such as DiGeorge Syndrome, Trisomy 21, and Kabuki syndrome. Therefore, uncovering the gene regulatory networks that govern all stages of heart development is essential towards designing novel diagnostic and therapeutic approaches for treating not only congenital heart defects but also adult cardiomyopathies.
This Special Issue of Cardiogenetics focused on “Gene Regulatory Networks and Transcription factors in Heart Development” aims to highlight new discoveries in genetic regulation of cardiac development through transcriptomic and epi-transcriptomic approaches. Recent advances in multimodal genomic analysis and the development of cutting-edge genetic and imaging tools have allowed us to gain deeper and more nuanced insights into multiple developmental processes. We would now like to invite you to submit your new and exciting work on unraveling these gene regulatory networks during cardiac development in different model systems using innovative approaches.
Dr. Tanvi Sinha
Guest Editor
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Keywords
- cardiac development
- gene regulatory networks
- gene regulation
- genomics
- transcriptomics
- epigenomics
- transcription factors
- chromatin
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