Expression Analyses for Biological Pathway Modeling in Drug Discovery
A special issue of BioTech (ISSN 2673-6284).
Deadline for manuscript submissions: closed (31 August 2014) | Viewed by 201
Special Issue Information
Dear Colleagues,
Developing new drugs and the identification of their targets is hard and expensive. High-throughput technologies provide for the first time the chance to comprehensively monitor the mode-of-action of small molecules on cellular level. The genomic era has caused a basic change in research, enabling scientists to look more systematically at biological systems. The complete sequencing of the human genome coupled with advances in automation and high-throughput technologies have afforded an important transformation in drug target discovery, towards systematic whole genome and proteome analyses. Novel proteomic techniques enable genome-wide annotation of function in several model organisms. Data derived from whole genome sequence, expression and functional analyses will help to identify causal genes in disease and significantly improve the process of target identification. Moreover, technological progresses in small molecule screening have resulted in the development of efficient and powerful platforms for elucidating the function of modulators of proteins. In addition, microarray based technologies are currently being used to identify targets of orphan small molecules. In this issue we are focusing on new results in microarray based drug discovery research. You are cordially invited to present new material that shows how microarray technologies can contribute to improve the understanding of the function of small molecules in biological networks.
Prof. Dr. Jacqueline Franke
Guest Editor
Submission
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Keywords
- drug discovery
- target identification
- chemical biology
- systems biology
- pathway analysis
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