Single-Molecule Tracking for Live Cells
A special issue of Biophysica (ISSN 2673-4125).
Deadline for manuscript submissions: 30 September 2026 | Viewed by 1029
Special Issue Editor
Interests: single molecules; single-molecule biophysics & biochemistry based on the stochastic nature of diffusion
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We have measured the anomalous diffusion in human prostate cancer cells that were transfected with an Alexa633 fluorescent RNA probe and co-transfected with enhanced green fluorescent protein-labeled argonaute2 protein via laser scanning microscopy. The image analysis arose from diffusion based on a “two-level system”. The trap was an interaction site where the diffusive motion was slowed down. Anomalous subdiffusive spreading occurred at cellular traps. The cellular traps were not immobile. We demonstrated how the novel analysis method of imaging data resulted in new information about the number of traps in the crowded and heterogeneous environment of a single human prostate cancer cell. The imaging data were consistent with and explained by modern ideas of the anomalous diffusion of mixed origins in live cells.
This Special Edition is about the single-molecule level versus the many-molecule level in single live cells and diluted liquids (solutions). The journal Biophysica contains groundbreaking and fundamental research on single-molecule tracking and measurements, while papers published in the journal Cells apply to more specific questions in cell biology. We would appreciate it if you would consider submitting a paper to this Special Edition of the journals Biophysica.
You may choose our Joint Special Issue in Cells.
Prof. Dr. Zeno Földes-Papp
Guest Editor
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Keywords
- single-molecule level
- many-molecule level
- biological cell
- diluted liquids
- single-molecule localization microscopy
- nanoscopy
- modeling
- diffusion
- theory
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