Vascular Endothelial Functions: Insights from Molecular Perspectives
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: closed (15 December 2023) | Viewed by 27345
Special Issue Editor
Special Issue Information
Dear Colleagues,
In addition to being a single cellular layer separating blood from underlying tissues, vascular endothelium executes multiple functions including angiogenesis, control of vascular tone and hemodynamics, participation in blood clotting, modulation of immune reactions, and exchange of substances between blood and tissues. Endothelial dysfunction or damage is a hallmark of major human pathologies such as cardiovascular diseases, diabetes, cancer, severe lung and brain injury and infectious diseases, including the global threat of COVID-19. Advancement in endothelial protection and correction of endothelial dysfunction requires identification of the key molecules that participate in signaling cascades, metabolic health, and macromolecule interaction networks in endothelial cells. Some of these molecules are predicted to gain pharmacologic value in emerging vasculoprotective therapies.
In this Special Issue, we hope to attract contributions elucidating molecular events underlying endothelial physiology and multiple faces of endothelial dysfunction, as well as contributions on endothelial pharmacology dealing with molecular mechanisms of the action of known and novel endothelial protective substances.
Dr. Vladimir P. Shirinsky
Guest Editor
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Keywords
- endothelium
- dysfunction
- barrier
- angiogenesis
- cytoskeletal and adhesive proteins
- transendothelial transport
- gene expression
- glycocalyx
- intracellular signaling
- metabolism
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