Multiple Sclerosis: From Early Diagnosis to Personalized Therapeutic Approaches
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 34
Special Issue Editor
2. Department of Health Sciences, University of Genoa, Genoa, Italy
Interests: multiple sclerosis; social determinants of health; environmental exposures; biostatistics
Special Issue Information
Dear Colleagues,
Multiple Sclerosis (MS) is a chronic immune-mediated disorder affecting the central nervous system and is characterized by demyelination, axonal loss, and neuroinflammation. MS can result in progressive physical and cognitive disabilities, leading to meaningful impairment of daily functioning. Globally, MS prevalence varies significantly by region, but the burden of MS is rising worldwide; there were 2.9 million people living with MS in 2023.
The recently introduced 2024 revisions of the McDonald diagnostic criteria aim to expedite the diagnosis of MS while preserving specificity, thereby diminishing the time to treatment initiation. Indeed, early treatment start has been associated with more favorable outcomes. Although MS remains an incurable disease, a wide range of disease-modifying therapies (DMTs) have been approved, aiming to reduce relapses, disability progression, and neuroradiologic activity, thereby improving the quality of life of individuals with MS. Approved DMTs differ widely in their mechanisms of action, clinical efficacy, safety profiles, and administration routes, and therefore a personalized therapeutic approach is essential.
This Special Issue highlights current knowledge and recent advances in MS, with a focus on diagnosis, therapeutic strategies, and individual well-being. We invite authors and investigators in this field to submit original research or review articles pertaining to this Special Issue, addressing (but not limited to) the following topics:
- Diagnosis, including clinical presentation, laboratory tests, paraclinical tools, advanced neuroimaging and artificial intelligence, application of 2024 revised criteria, and diagnosis across diverse demographic or clinical populations and barriers;
- Therapy, including approved DMTs, personalized therapeutic strategies, emerging therapies, hematopoietic stem cell transplantation, and study designs.
Dr. Marta Ponzano
Guest Editor
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Keywords
- multiple sclerosis
- diagnosis
- revised criteria
- neuroimaging
- therapy
- disability
- individual well-being
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