Special Issue "Synaptic Plasticity in Health and Disease"

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Neurologic Disease".

Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 296

Special Issue Editor

1. Departamento de Fisiología Médica y Biofísica, Instituto de Biomedicina de Sevilla, Universidad de Sevilla, Sevilla, Spain
2. IBIS, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain
Interests: local translation; trisomy 21; mTOR; synaptic plasticity; memory; learning; hippocampus

Special Issue Information

Dear Colleagues,

Synaptic plasticity represents the neural basis of learning and memory, and is required for adaptative behaviour. Since the seminal paper from Bliss and Lomo (1973) which described hippocampal long-term potentiation (LTP), several forms of LTP and long-term depression (LTD) have been discovered and characterized in different brain regions. Moreover, it is now clear that synaptic plasticity is compromised in experimental models of intellectual disabilities such as down syndrome (DS), fragile X, or Rett syndrome; in neurodegenerative brain diseases as Alzheimer’s disease (AD) and Parkinson’s disease (PD); and in other brain disorders, such as autism spectrum disorders (ASDs), to list just a few examples.

This Special Issue will focus on: (1) the molecular basis of the different forms of synaptic plasticity in the context of the healthy brain, and (2) the plasticity alterations found in brain diseases and disorders, with special interest in the signaling pathways and molecular mechanisms affected. Understanding synaptic plasticity in health and disease could help to identify key targets, as a first step for developing pharmacological treatments aimed to improve learning/memory in individuals affected by those brain disorders/diseases.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to): molecular mechanisms of plasticity, synaptic proteomics in plasticity, proteomics and electrophysiological studies in models of DS, fragile X, Rett syndrome, ASD, AD, PD and other brain disorders/diseases with affected plasticity.

I look forward to receiving your contributions.

Dr. María Luz Montesinos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • LTP
  • LTD
  • plasticity-signaling pathways
  • electrophysiology
  • learning
  • memory
  • intellectual disability
  • brain disorders
  • synaptic plasticity

Published Papers

There is no accepted submissions to this special issue at this moment.
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