Pharmacology and Pharmacokinetics of Cancer Drugs
Special Issue Information
Dear Colleagues,
Over the past several decades, the number of modalities and mechanisms of anti-cancer drugs has dramatically increased beyond traditional low molecular weight cytotoxic agents. A plethora of biologics including multi-specific formats, antibody drug conjugates, cellular therapies, gene therapies, radioligand therapies and highly targeted chemical compounds have opened up new possibilities and raised new questions to understand their pharmacology, pharmacodynamics and pharmacokinetics.
Understanding the pharmacokinetics and pharmacodynamics of anti-cancer drugs at the sub-cellular, cellular and organism level is critical for optimal drug design, patient selection, precision medicine and justification of dose/regimen. Complementing the biological understanding, tools and methodologies to advance model-informed drug development (MIDD), as a potential enabler of efficient oncology drug development and its regulatory application, are additional focal points of interdisciplinary research interest.
With this Special Edition, we welcome original research and review articles in this area, with the aim to highlight key developments and topics for future investigation.
Dr. Sukyung Woo
Dr. Bart S. Hendriks
Dr. Jennifer Dong
Guest Editors
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Keywords
- Pharmacokinetics
- Pharmacodynamics
- Quantitative pharmacology
- Model-informed drug development
- Drug interactions
- Cellular pharmacology
- Sub-cellular distribution and drug delivery
- Drug transport
- System/mechanistic and/or population modeling
- Physiologically based PK modeling
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Published Papers
Biomedicines - ISSN 2227-9059