Molecular Research on Non-small Cell Lung Cancer
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 5912
Special Issue Editor
Interests: cancer; chemoresistance; signal transduction pathway; RTK (receptor tyrosine kinase); phytochemicals
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
There are two types of lung cancer, small-cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC), but NSCLC is the first leading cause of death in terms of mortality rate. Strategies for the treatment of NSCLC patients vary widely from conventional approaches including surgical resection, radiation, and chemotherapy to emerging therapies such as target therapy focusing on various oncogenes, immunotherapy, and combinational therapy. This Special Issue focuses on “Molecular Research on Non-Small Cell Lung Cancer". Recently, various oncogenes have been found to be overexpressed in NSCLC and highly correlated with aggressiveness, epithelial-to-mesenchymal transition, and chemoresistance, since they transduce multiple signals for cell growth, survival, proliferation, invasion, migration, angiogenesis, and inhibition of apoptosis. Therefore, customized therapy targeting these oncogenes may be a potent and practical target for the successful treatment of NSCLC, and this will be the focus of this Special Issue. Review manuscripts as well as original investigations demonstrating novel therapeutic targets and candidates to be tested in clinical trials and the underlying molecular mechanisms and crosstalk of signaling with other signaling pathways will be considered for publication.
Dr. Chuhee Lee
Guest Editor
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Keywords
- non-small cell lung carcinoma
- oncogenes
- epithelial-to-mesenchymal transition
- chemoresistance
- signaling pathways
- molecular mechanisms
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