Mechanobiology and Extracellular Vesicle-Based Strategies for Osteochondral Regeneration

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 374

Special Issue Editor


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Guest Editor
Arthritis Clinical and Research Center, Peking University People’s Hospital, Beijing 100044, China
Interests: cartilage and meniscus tissue engineering

Special Issue Information

Dear Colleagues,

This Special Issue will focus on emerging strategies for musculoskeletal regeneration by integrating biomechanics, stem cell biology, extracellular vesicles, and advanced tissue engineering approaches. We welcome original research articles and reviews that explore the mechanobiological regulation of stem cell fate, the role of extracellular vesicles in osteoarthritis pathogenesis and therapy, and the development of osteochondral organoids or biomaterial-based systems for translational applications. The goal is to provide a multidisciplinary platform linking fundamental mechanisms with innovative therapeutic strategies for osteoarthritis and related joint diseases.

Dr. Zhen Yang
Guest Editor

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Keywords

  • biomechanics
  • stem cells
  • osteoarthritis
  • tissue engineering
  • extracellular vesicles

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Published Papers (1 paper)

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Review

17 pages, 1928 KB  
Review
Beyond ER Stress: The Pleiotropic Roles of XBP1 in Development and Regeneration
by Delan Huang, Fan Gu, Jingzhi Ma and Zhi Chen
Biomedicines 2025, 13(11), 2663; https://doi.org/10.3390/biomedicines13112663 - 30 Oct 2025
Viewed by 212
Abstract
This review synthesizes current knowledge on the roles of X-box binding protein 1 (XBP1) in development and regenerative medicine. XBP1 is defined as a key transcription factor that regulates biological processes from embryogenesis to adult tissue homeostasis via both endoplasmic reticulum(ER) stress-dependent and [...] Read more.
This review synthesizes current knowledge on the roles of X-box binding protein 1 (XBP1) in development and regenerative medicine. XBP1 is defined as a key transcription factor that regulates biological processes from embryogenesis to adult tissue homeostasis via both endoplasmic reticulum(ER) stress-dependent and independent mechanisms. Evidence for its regulatory role in cell fate determination and tissue maintenance across multiple systems is presented. The therapeutic potential of targeting XBP1 is explored, particularly for the regeneration of skeletal muscle, skin, and bone. Critical future research priorities are outlined, such as deciphering the precise functions of the Inositol requiring enzyme 1 (IRE1α)/XBP1 signaling axis and evaluating the long-term safety of its modulation. XBP1 is thus confirmed as a prime target for advancing developmental biology and pioneering new regenerative therapies. Full article
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