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Biomedicines
Special Issues
Mechanisms and Novel Therapeutic Approaches for Gliomas
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Mechanisms and Novel Therapeutic Approaches for Gliomas

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 4499

Special Issue Editor

Dr. Maria V. Chatziathanasiadou

E-Mail Website
Guest Editor
Honorary Research Associate, Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK
Interests: glioblastoma; metabolic therapies; immunotherapies; tumour microenvironment; cancer drug discovery

Special Issue Information

Dear Colleagues,

Gliomas, the most common type of primary malignant brain tumour, present significant clinical challenges. This is mainly due to their invasive nature, intratumour heterogeneity, immunosuppressive microenvironment, and the presence of the blood–brain barrier. Little progress has been achieved in glioma treatment over the last few decades, while the main therapeutic options are surgery, radiotherapy, and chemotherapy. Thus, there is an imperative need to deepen our current understanding of glioma mechanisms and develop cutting-edge therapeutic strategies.

This Special Issue aims to cover molecular and cellular glioma mechanisms, including molecular markers, signaling, tumour landscape, cell crosstalk, and immunity, as well as novel therapeutic approaches, such as metabolic therapies, immunotherapies, newly designed and repurposed drugs, and combination treatments.

We also welcome review manuscripts that present recently discovered molecular markers, therapeutic targets, tumour landscape characteristics, or innovative therapies from preclinical studies and clinical trials.

Dr. Maria V. Chatziathanasiadou
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • glioma
  • molecular mechanisms
  • signaling
  • tumour immunity
  • tumour metabolism
  • tumour microenvironment
  • metabolic therapies
  • immunotherapies
  • combination treatment

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Published Papers (2 papers)

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15 pages, 1415 KiB  
Review
Amino Acid Deprivation in Glioblastoma: The Role in Survival and the Tumour Microenvironment—A Narrative Review
by Keven Du, Leila Grocott, Giulio Anichini, Kevin O’Neill and Nelofer Syed
Biomedicines 2024, 12(11), 2481; https://doi.org/10.3390/biomedicines12112481 - 29 Oct 2024
Cited by 2 | Viewed by 1784
Abstract
Background: Glioblastoma is the most common and aggressive primary brain tumour, characterised by its invasive nature and complex metabolic profile. Emerging research highlights the role of amino acids (AAs) in glioblastoma metabolism, influencing tumour growth and the surrounding microenvironment. Methods: This narrative review [...] Read more.
Background: Glioblastoma is the most common and aggressive primary brain tumour, characterised by its invasive nature and complex metabolic profile. Emerging research highlights the role of amino acids (AAs) in glioblastoma metabolism, influencing tumour growth and the surrounding microenvironment. Methods: This narrative review synthesises recent pre-clinical studies focusing on the metabolic functions of AAs in glioblastoma. Key areas include the effects of AA deprivation on tumour growth, adaptive mechanisms, and the tumour microenvironment. Results: The effects related to arginine, glutamine, methionine, and cysteine deprivation have been more extensively reported. Arginine deprivation in arginine-auxotrophic glioblastomas induces apoptosis and affects cell adhesion, while glutamine deprivation disrupts metabolic pathways and enhances autophagy. Methionine and cysteine deprivation impact lipid metabolism and ferroptosis. Tumour adaptive mechanisms present challenges, and potential compensatory responses have been identified. The response of the microenvironment to AA deprivation, including immune modulation, is critical to determining therapeutic outcomes. Conclusions: Targeting AA metabolism offers a promising approach for glioblastoma treatment, with potential targeted drugs showing clinical promise. However, the complexity of tumour adaptive mechanisms and their impact on the microenvironment necessitates further research to optimise combination therapies and improve therapeutic efficacy. Full article
(This article belongs to the Special Issue Mechanisms and Novel Therapeutic Approaches for Gliomas)
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18 pages, 1782 KiB  
Systematic Review
Current Applications of Raman Spectroscopy in Intraoperative Neurosurgery
by Daniel Rivera, Tirone Young, Akhil Rao, Jack Y. Zhang, Cole Brown, Lily Huo, Tyree Williams, Benjamin Rodriguez and Alexander J. Schupper
Biomedicines 2024, 12(10), 2363; https://doi.org/10.3390/biomedicines12102363 - 16 Oct 2024
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Abstract
Background: Neurosurgery demands exceptional precision due to the brain’s complex and delicate structures, necessitating precise targeting of pathological targets. Achieving optimal outcomes depends on the surgeon’s ability to accurately differentiate between healthy and pathological tissues during operations. Raman spectroscopy (RS) has emerged as [...] Read more.
Background: Neurosurgery demands exceptional precision due to the brain’s complex and delicate structures, necessitating precise targeting of pathological targets. Achieving optimal outcomes depends on the surgeon’s ability to accurately differentiate between healthy and pathological tissues during operations. Raman spectroscopy (RS) has emerged as a promising innovation, offering real-time, in vivo non-invasive biochemical tissue characterization. This literature review evaluates the current research on RS applications in intraoperative neurosurgery, emphasizing its potential to enhance surgical precision and patient outcomes. Methods: Following PRISMA guidelines, a comprehensive systematic review was conducted using PubMed to extract relevant peer-reviewed articles. The inclusion criteria focused on original research discussing real-time RS applications with human tissue samples in or near the operating room, excluding retrospective studies, reviews, non-human research, and other non-relevant publications. Results: Our findings demonstrate that RS significantly improves tumor margin delineation, with handheld devices achieving high sensitivity and specificity. Stimulated Raman Histology (SRH) provides rapid, high-resolution tissue images comparable to traditional histopathology but with reduced time to diagnosis. Additionally, RS shows promise in identifying tumor types and grades, aiding precise surgical decision-making. RS techniques have been particularly beneficial in enhancing the accuracy of glioma surgeries, where distinguishing between tumor and healthy tissue is critical. By providing real-time molecular data, RS aids neurosurgeons in maximizing the extent of resection (EOR) while minimizing damage to normal brain tissue, potentially improving patient outcomes and reducing recurrence rates. Conclusions: This review underscores the transformative potential of RS in neurosurgery, advocating for continued innovation and research to fully realize its benefits. Despite its substantial potential, further research is needed to validate RS’s clinical utility and cost-effectiveness. Full article
(This article belongs to the Special Issue Mechanisms and Novel Therapeutic Approaches for Gliomas)
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