New Perspectives on Systemic Amyloidosis: From Pathophysiology to Therapy

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".

Deadline for manuscript submissions: 30 April 2026

Special Issue Editors


E-Mail Website
Guest Editor
Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary
Interests: systemic amyloidosis; heart failure; cardio-oncology

E-Mail Website
Guest Editor
Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary
Interests: amyloidosis; cardiomyopathy

Special Issue Information

Dear Colleagues,

Although previously considered a rare, difficult-to-treat disease with poor prognosis, our perspective on systemic amyloidosis has been changed a lot in recent years. It is known that the presence and degree of the cardiac involvement is one of the most important prognostic factors. Today, widely available, cheap and fast diagnostic tools provide the opportunity of easy and early detection of the most common forms of the systemic/cardiac amyloidosis. Accordingly, the number of patients diagnosed with amyloidosis has been rapidly growing. However, data suggest that the condition is still largely underdiagnosed, and real prevalence of the disease is not known. Moreover, novel disease-modifying, specific therapies have become available in all major forms of systemic amyloidosis: in light chain amyloidosis, hereditary and wild-type transthyretin amyloidosis. The new therapies have led to improving survival. Advances in the diagnosis and treatment of amyloidosis have put the disease into the focus of scientific interest, resulting in intensive research and evolving knowledge in the field. However, numerous questions still remained unsolved, and patient management is frequently challenging.

This Special Issue primarily focuses on clinical aspects of systemic amyloidosis, like patient monitoring, treatment, prognosis and clinical challenges. Studies on pathophysiology, mechanism of amyloid formation. We invite original research articles, reviews as well.

Dr. Zoltán Pozsonyi
Dr. Katalin Révész
Guest Editors

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Keywords

  • systemic amyloidosis
  • cardiac amyloidosis
  • light chain amyloidosis
  • hereditary transthyretin amyloidosis
  • wild-type transthyretin amyloidosis
  • amyloidogenesis
  • disease-modifying treatments
  • heart failure with preserved ejection fraction

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