New Perspectives on Systemic Amyloidosis: From Pathophysiology to Therapy
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 65
Special Issue Editors
Interests: systemic amyloidosis; heart failure; cardio-oncology
Special Issue Information
Dear Colleagues,
Although previously considered a rare, difficult-to-treat disease with poor prognosis, our perspective on systemic amyloidosis has changed substantially in recent years. Cardiac involvement is now recognized as one of the most important prognostic factors. Today, widely available, inexpensive, and rapid diagnostic tools provide opportunities for earlier and easier detection of the most common forms of the systemic and cardiac amyloidosis. Consequently, the number of diagnosed patients has increased rapidly. Nonetheless, data suggest that the condition remains largely underdiagnosed, and its true prevalence is still unknown.
In parallel, novel disease-modifying therapies have become available for all major forms of systemic amyloidosis, including light chain amyloidosis, as well as hereditary and wild-type transthyretin amyloidosis. These new treatments have significantly improved survival. Advances in diagnosis and therapy have brought amyloidosis into the focus of scientific interest, driving intensive research and expanding knowledge in the field. However, many questions remain unanswered, and patient management continues to pose significant challenges.
This Special Issue will focus primarily on the clinical aspects of systemic amyloidosis, including patient monitoring, treatment, prognosis, and clinical challenges. Studies addressing pathophysiology and the mechanisms of amyloid formation as also welcome. We invite the submission of original research articles and reviews.
Dr. Zoltán Pozsonyi
Dr. Katalin Révész
Guest Editors
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Keywords
- systemic amyloidosis
- cardiac amyloidosis
- light chain amyloidosis
- hereditary transthyretin amyloidosis
- wild-type transthyretin amyloidosis
- amyloidogenesis
- disease-modifying treatments
- heart failure with preserved ejection fraction
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