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Biomedicines
Special Issues
Nano-Bio Interface Toxicity and Applications
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Nano-Bio Interface Toxicity and Applications

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Materials and Nanomedicine".

Deadline for manuscript submissions: closed (30 November 2020) | Viewed by 9766

Special Issue Editor

Dr. Tapas Sen

E-Mail Website
Guest Editor
School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, UK
Interests: nanoscience; nanotechnology; nanomedicine; nano-water; nano-catalysis; nano-biosensor
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The fate of nanomaterials in a biological environment for their applications in medicine is currently a hot topic due to the formation of protein corona, which limits their use in biomedicine. Therefore, functionalisation of inorganic/organic nanoparticles with biomolecules such as oligonucleotides, antibodies, protein and disease specific biomarkers is a topical area of research receiving a huge amount of interest from experts in biomedicine. In this Special Issue, we welcome research articles, communications and reviews on application of functional nanomaterials in biomedicine by exploring the formation of protein corona, in the nano–bio interface, a range of biomolecules conjugated nanoparticles and their toxicity.

Dr. Tapas Sen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nano–bio interface
  • protein corona
  • toxicity
  • biomarkers
  • nanomedicine
  • theranostic

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Published Papers (2 papers)

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Research

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14 pages, 3324 KiB  
Article
Cytocompatibility of Bilayer Scaffolds Electrospun from Chitosan/Alginate-Chitin Nanowhiskers
by Valentina A. Petrova, Alexey S. Golovkin, Alexander I. Mishanin, Dmitry P. Romanov, Daniil D. Chernyakov, Daria N. Poshina and Yury A. Skorik
Biomedicines 2020, 8(9), 305; https://doi.org/10.3390/biomedicines8090305 - 24 Aug 2020
Cited by 23 | Viewed by 3674
Abstract
In this work, a bilayer chitosan/sodium alginate scaffold was prepared via a needleless electrospinning technique. The layer of sodium alginate was electrospun over the layer of chitosan. The introduction of partially deacetylated chitin nanowhiskers (CNW) stabilized the electrospinning and increased the spinnability of [...] Read more.
In this work, a bilayer chitosan/sodium alginate scaffold was prepared via a needleless electrospinning technique. The layer of sodium alginate was electrospun over the layer of chitosan. The introduction of partially deacetylated chitin nanowhiskers (CNW) stabilized the electrospinning and increased the spinnability of the sodium alginate solution. A CNW concentration of 7.5% provided optimal solution viscosity and structurization due to electrostatic interactions and the formation of a polyelectrolyte complex. This allowed electrospinning of defectless alginate nanofibers with an average diameter of 200–300 nm. The overall porosity of the bilayer scaffold was slightly lower than that of a chitosan monolayer, while the average pore size of up to 2 μm was larger for the bilayer scaffold. This high porosity promoted mesenchymal stem cell proliferation. The cells formed spherical colonies on the chitosan nanofibers, but formed flatter colonies and monolayers on alginate nanofibers. The fabricated chitosan/sodium alginate bilayer material was deemed promising for tissue engineering applications. Full article
(This article belongs to the Special Issue Nano-Bio Interface Toxicity and Applications)
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Review

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28 pages, 6436 KiB  
Review
Iron Oxide-Based Magneto-Optical Nanocomposites for In Vivo Biomedical Applications
by Nisha Lamichhane, Shalini Sharma, Parul, Anita Kamra Verma, Indrajit Roy and Tapas Sen
Biomedicines 2021, 9(3), 288; https://doi.org/10.3390/biomedicines9030288 - 12 Mar 2021
Cited by 27 | Viewed by 4993
Abstract
Iron oxide nanoparticles (IONPs) have played a pivotal role in the development of nanomedicine owing to their versatile functions at the nanoscale, which facilitates targeted delivery, high contrast imaging, and on-demand therapy. Some biomedical inadequacies of IONPs on their own, such as the [...] Read more.
Iron oxide nanoparticles (IONPs) have played a pivotal role in the development of nanomedicine owing to their versatile functions at the nanoscale, which facilitates targeted delivery, high contrast imaging, and on-demand therapy. Some biomedical inadequacies of IONPs on their own, such as the poor resolution of IONP-based Magnetic Resonance Imaging (MRI), can be overcome by co-incorporating optical probes onto them, which can be either molecule- or nanoparticulate-based. Optical probe incorporated IONPs, together with two prominent non-ionizing radiation sources (i.e., magnetic field and light), enable a myriad of biomedical applications from early detection to targeted treatment of various diseases. In this context, many research articles are in the public domain on magneto-optical nanoparticles; discussed in detail are fabrication strategies for their application in the biomedical field; however, lacking is a comprehensive review on real-life applications in vivo, their toxicity, and the prospect of bench-to-bedside clinical studies. Therefore, in this review, we focused on selecting such important nanocomposites where IONPs become the magnetic component, conjugated with various types of optical probes; we clearly classified them into class 1 to class 6 categories and present only in vivo studies. In addition, we briefly discuss the potential toxicity of such nanocomposites and their respective challenges for clinical translations. Full article
(This article belongs to the Special Issue Nano-Bio Interface Toxicity and Applications)
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