Advances in Aging and Skeletal Diseases

Dear Colleagues,

As the global population continues to age, skeletal diseases such as osteoporosis and bone metastatic cancers are becoming increasingly prevalent, imposing a significant socioeconomic burden worldwide. Aging is driven by fundamental mechanisms, including telomere shortening, genomic instability, loss of proteostasis, mitochondrial dysfunction, deregulated nutrient sensing, stem cell exhaustion, altered intercellular communication, and cellular senescence, that contribute to the development and progression of these skeletal disorders. Recent studies, predominantly in animal models, have demonstrated that manipulating these aging mechanisms can extend one’s healthspan, i.e., the period of life free from chronic diseases. Given that these hallmarks of aging are interconnected, targeting one may simultaneously prevent or delay multiple comorbidities, offering a paradigm shift from the current approach of treating individual diseases.

This Special Issue will showcase cutting-edge research on skeletal disorders’ pathophysiological mechanisms, predictive biomarkers, and preclinical therapeutic strategies, with a particular focus on osteoporosis and bone metastatic cancers. We invite authors to contribute original research articles and comprehensive reviews that advance our understanding in these areas.

The topics of interest include but are not limited to the following:

• Pathophysiological studies related to skeletal diseases;
• Molecular, biochemical, and biomechanical mechanisms involved in skeletal disorders’ etiology and progression;
• Identification and validation of biomarkers useful for early diagnosis and/or predictive of prognosis;
• Preclinical research on potential drugs and cell-based therapies for the treatment of skeletal disorders, particularly osteoporosis and bone metastatic cancers.

Dr. Japneet Kaur
Dr. Mohamad Alaa Terkawi
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.