Understanding Chronic Neurological Diseases: Pathophysiology, Biomarkers, and Therapeutic Approaches

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 71

Special Issue Editor

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Guest Editor
Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M Health Science Center, College Station, TX 77807, USA
Interests: Alzheimer’s disease; β-secretase; β-amyloid; BACE-1; dementia; epilepsy

Special Issue Information

Dear Colleagues,

"Understanding Chronic Neurological Diseases: Pathophysiology, Biomarkers, and Therapeutic Approaches" is a Special Issue that delves into the intricate nature of chronic neurological diseases, probing the latest advancements in understanding their pathophysiology, identifying biomarkers crucial for diagnosis and prognosis, and progressing with innovative treatment strategies/methodologies. Chronic neurological diseases, such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis, and epilepsy pose significant challenges to patients, caregivers, and healthcare professionals worldwide. This issue covers a wide range of topics related to the understanding of different disease mechanisms, the identification of biomarkers for diagnosis and prognosis, and the development of innovative treatment strategies.

The Special Issue begins by examining the intricate pathophysiological mechanisms that underlie chronic neurological diseases. By unraveling the molecular and cellular processes involved in disease development and progression, researchers gain invaluable insights into potential therapeutic targets and intervention strategies. This foundational understanding forms the basis of subsequent discussions regarding biomarkers and treatment approaches.

The identification of reliable biomarkers is a crucial aspect of managing chronic neurological diseases. Biomarkers provide objective measures that aid in accurate diagnosis, disease monitoring, and prognostic assessment. This Special Issue explores various types of biomarkers, including genetic markers, imaging markers, cerebrospinal fluid biomarkers, and blood-based biomarkers. These biomarkers hold great potential for improving diagnostic accuracy, predicting disease progression, and assessing treatment response, thereby enabling personalized and targeted therapeutic interventions.

The Special Issue also highlights the development of innovative treatment strategies for chronic neurological diseases. Researchers and clinicians are continuously exploring pharmacological and non-pharmacological interventions in order to slow disease progression, alleviate symptoms, and improve patients' quality of life. The issue showcases emerging approaches such as gene therapy, immunotherapy, stem cell therapy, and neurostimulation techniques, which offer promising avenues for more effective and personalized treatments.

Personalized medicine is a key theme emphasized in the Special Issue. The recognition that each patient is unique in terms of genetic makeup, biomarker profiles, and disease subtypes highlights the importance of individualized treatment strategies. By considering these personalized factors, clinicians can optimize treatment efficacy, minimize adverse effects, and improve overall patient outcomes.

In summary, "Understanding Chronic Neurological Diseases: Pathophysiology, Biomarkers, and Therapeutic Approaches" is a Special Issue addressing the complexities of chronic neurological diseases. By exploring pathophysiology, biomarkers, and treatment strategies, this issue aims to enhance our understanding of these conditions, paving the way for improved diagnosis, management, and therapeutic interventions. The insights and advancements presented in this Special Issue contribute to the global efforts in combating chronic neurological diseases and improving the lives of affected individuals.

Dr. Tanveer Singh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • chronic neurological diseases
  • pathophysiology
  • biomarkers
  • novel therapeutic approaches

Published Papers

This special issue is now open for submission.
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