Precision Medicine in GU Cancers: New Challenges and New Horizons

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 2281

Special Issue Editors


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Guest Editor
1. Oncologia Medica A, Policlinico Umberto 1, La Sapienza Università Di, 00161 Roma, Italy
2. Department of Medico-Surgical Sciences and Biotechnology, Sapienza University of Rome, 00161 Rome, Italy
Interests: hepatocellular carcinoma; bone metastasis; colorectal tumors; kidney tumors; gastric cancers

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Guest Editor
Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy
Interests: urothelial carcinoma; prostate cancer; renal cell carcinoma; testicular cancer; penile cancer

Special Issue Information

Dear Colleagues,

According to global cancer statistics, genitourinary (GU) cancers constitute the most common cancer worldwide with a high morbidity and mortality.

Nowadays, the therapeutic landscape of this disease is rapidly changing and novel treatments have shown interesting results in terms of survival and quality of life. 

Unfortunately, biomarkers useful in choosing the best treatment for patients remain an unmet need, even if they can be considered as an emerging research field. So, the aim of precision medicine is to guide clinicians in the decision-making process in order to select the best treatment and to avoid toxicities.

In this Special Issue of Biomedicines, we present a series of high-quality review and research papers concerning various urologic malignancies, illustrating the current developments in precision medicine for these cancers.

  • Selecting patients for immunotherapy: the role of PDL-1 in urothelial carcinoma.
  • Selecting patients for bladder-sparing approach: the new frontier for precision medicine in urothelial carcinoma.
  • Liquid biopsy in mRCC: what do we need to look for?
  • CDK inhibitors for prostate cancer.
  • Precision medicine for penile cancer: far away from target therapy?
  • HER2 status in bladder cancer.

Prof. Dr. Daniele Santini
Dr. Marco Stellato
Guest Editors

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Keywords

  • urothelial carcinoma
  • bladder cancer
  • upper tract urothelial carcinoma
  • renal cell carcinoma
  • liquid biopsy
  • prostate cancer
  • CDK inhibitors
  • HER2
  • penile carcinoma

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Published Papers (1 paper)

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Research

11 pages, 1240 KiB  
Article
Impacts of Mir146a Genotypes on Bladder Cancer Risk in Taiwan
by Bo-Ren Wang, Wen-Shin Chang, Cheng-Hsi Liao, Yun-Chi Wang, Jian Gu, Da-Tian Bau and Chia-Wen Tsai
Biomedicines 2023, 11(5), 1396; https://doi.org/10.3390/biomedicines11051396 - 8 May 2023
Cited by 3 | Viewed by 1852
Abstract
The aim of this study was to investigate the association between single-nucleotide polymorphisms (SNPs) in mir146a and mir196a and bladder cancer (BLCA) risk in Taiwan. The genotypes of mir146a rs2910164 and mir196a rs11614913 were determined in 375 BLCA patients and 375 healthy controls [...] Read more.
The aim of this study was to investigate the association between single-nucleotide polymorphisms (SNPs) in mir146a and mir196a and bladder cancer (BLCA) risk in Taiwan. The genotypes of mir146a rs2910164 and mir196a rs11614913 were determined in 375 BLCA patients and 375 healthy controls using PCR-RFLP methodology, and their associations with BLCA risk were evaluated. The study also measured the serum expression level of mir146a using quantitative RT-PCR. The results showed that the distributions of CC, CG and GG genotypes of mir146a rs2910164 were 31.7%, 45.6% and 22.7% in the control group, and 21.9%, 44.3% and 33.8% in the case group, respectively. In logistic regression analyses, the heterozygous variant genotype CG carriers showed a marginally significant association with increased BLCA risk (OR = 1.41, 95% CI = 0.99–2.01), while the homozygous variant genotype GG carriers had a 2.17-fold increased risk of BLCA (OR = 2.17, 95%CI = 1.46–3.21). Moreover, carriers of the GG/CG genotypes had significantly higher serum levels of mir146a than those with the CC genotype (p < 0.0001), indicating a genotype–phenotype correlation. In contrast, mir196a rs11614913 was not associated with BLCA risk. Therefore, the genotypes of mir146a rs2910164 may serve as a useful biomarker for predicting the risk of BLCA. Full article
(This article belongs to the Special Issue Precision Medicine in GU Cancers: New Challenges and New Horizons)
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