Updates on Tissue Repair and Regeneration Pathways

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 650

Special Issue Editors


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Guest Editor
“Aurel Ardelean” Institute of Life Sciences, Vasile Goldis Western University of Arad, 86 Revolutiei Av., 310144 Arad, Romania
Interests: regenerative medicine; phytotherapy; liver fibrosis; drug delivery systems
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Faculty of Veterinary Medicine, University of Life Sciences “King Mihai I” from Timisoara, 300645 Timișoara, Romania
Interests: regenerative biology; phytotherapy; molecular mechanisms of cellular senescence; cellular oxidative stress
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Special Issue Information

Dear Colleagues,

The occurrence of tissue injuries, which can be produced in various ways, requires the engagement of targeted tissue repair and regeneration mechanisms that are specific and necessary for the replacement and renewal of altered tissue. The processes of tissue regeneration and repair involve the co-optation and integration of complex cellular processes, such as cellular signaling, the migration of the necessary cell populations, their proliferation, the formation of the extracellular matrix, and the management of the distribution of energy reserves and substance reserves. Humans have a particularly heterogeneous regeneration mechanism depending on the damaged tissue, the energy requirements and metabolic rate as a function of age, or various associated pathological conditions and the therapeutic interventions performed. The knowledge of the molecular pathways involved in these processes has led to the discovery of some molecules with a positive effect in modulating repair and regeneration processes. Despite the obvious advances made in medicine in relation to this field, there is a need to study these mechanisms in depth, especially with regard to the signaling pathways involved, the origin of the effector cells, the influence of injuries on the signaling pathways and the cells involved, and the influence of the microenvironment where all of these components must collaborate to achieve tissue repair with preserved architecture and function.

We hope that this Special Issue will serve as a platform to present evaluations of the mechanisms of tissue repair and regeneration, ultimately leading to the enrichment of data in this field and offering some practical solutions in modulating the processes involved in tissue regeneration.

We look forward to receiving your contributions and hope that we can lead the progress of this branch of medicine.

Dr. Cornel Baltă
Dr. Oana-Maria Boldura
Guest Editors

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Keywords

  • tissue repair
  • tissue regeneration
  • molecular pathways involved in repair and regeneration
  • extracellular matrix
  • drug delivery systems

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Published Papers (1 paper)

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Research

14 pages, 4979 KB  
Article
Regeneration of the Gastrointestinal Tract After Using a Small Intestine Submucosa Patch—A Rat Model
by Tamas Toth, Radu-Alexandru Prisca, Emoke Andrea Szasz, Reka Borka-Balas and Angela Borda
Biomedicines 2025, 13(10), 2397; https://doi.org/10.3390/biomedicines13102397 - 30 Sep 2025
Abstract
Background: Necrotizing enterocolitis (NEC) is a life-threatening condition characterized by necrosis of the gastrointestinal tract caused by hypoperfusion and hypoxia-induced inflammation. Surgical treatment often requires resection, with high morbidity and mortality. Intestinal tissue engineering using absorbable biomaterials represents a potential alternative. Small intestinal [...] Read more.
Background: Necrotizing enterocolitis (NEC) is a life-threatening condition characterized by necrosis of the gastrointestinal tract caused by hypoperfusion and hypoxia-induced inflammation. Surgical treatment often requires resection, with high morbidity and mortality. Intestinal tissue engineering using absorbable biomaterials represents a potential alternative. Small intestinal submucosa (SIS) is a biodegradable extracellular matrix (ECM) scaffold that may facilitate regeneration of the native tissue. Objectives: The aim of our study is to investigate the regenerative potential of SIS in a rat model with multiple gastrointestinal defects. Methods: In rats, after a midline laparotomy, an approximately 1 cm full-thickness incision was performed on the anterior gastric wall, on the antimesenteric side of the small and large intestine, each covered with an SIS patch. After three weeks, the graft sites and adjacent fragments were harvested and fixed in 10% neutral buffered formalin. Cross-sections of the grafted area were processed and stained with hematoxylin and eosin for histologic analysis. Results: Among the fifteen Wistar rats used in the study, the survival rate was 80% (12/15). Macroscopic examination of the abdominal cavity after the second surgery showed no complications. Adhesions were present in 92% (11/12). Histological examination demonstrated complete mucosal coverage in all stomach samples, nine of the small intestine, and ten of the large intestine. Mild fibrosis with minimal inflammatory infiltrates predominated. Ulceration with granulation tissue replacement was observed in three small intestine samples. Foreign body reactions were restricted to suture sites. Conclusions: In this multifocal injury model, SIS integrated effectively and supported early regenerative healing across gastric, small-intestinal, and colonic sites at 3 weeks. These data support further studies with longer follow-up, quantitative histology and functional assessment, and evaluation in neonatal-relevant large animal models to determine translational potential for NEC surgery. Full article
(This article belongs to the Special Issue Updates on Tissue Repair and Regeneration Pathways)
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