Rheumatology Diseases: Advances in the Understanding of Pathogenesis, Biomarker Research and Treatment Target
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 31 July 2025 | Viewed by 219
Special Issue Editor
2. Medical Faculty, Sofia University “St. Kliment Ohridski”, 1407 Sofia, Bulgaria
Interests: pathogenesis of rheumatic diseases; epigenetic modifications; miRNA expression; new imaging modalities in rheumatology; target therapies
Special Issue Information
Dear Colleagues,
Autoimmune rheumatic diseases (AIRDs) are chronic, systemic diseases characterized by unknown etiology and pathogenesis. Recent studies have revealed the multifactorial basis of AIRD with the leading role of genetic and epigenetic factors as well as environmental factors in disease predisposition, onset and progression. Epigenetic factors, including DNA methylation, histone modifications and deregulated miRNA expression in circulation, in addition to local expression, play an important role in the pathogenesis of AIRD by regulating key biological pathways.
Significant advances have been made in the search for serological and proteomic biomarkers, which could be used as predictors of disease onset and severity. The implementation of newer imaging technics offers an earlier diagnosis rate and safer follow-up of these subtypes of patients.
The recent advances in our understanding of the pathogenesis of AIRD enable the development of effective therapeutic agents, including biological and target therapies minimizing the side-effects of non-selective immunosuppressive agents. Recent studies have shown the effects of new therapeutic strategies, including the use of CAR-T cell therapies, and Bi-specific T-cell engagers, in rheumatology clinical practice, which could allow us to revolutionize the treatment approach in this type of autoimmune diseases.
Dr. Russka Shumnalieva
Guest Editor
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Keywords
- pathogenesis of rheumatic diseases
- epigenetic modifications
- biomarkers
- new imaging modalities
- therapeutic strategies
- new treatment targets
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