Modulation of Gut Microbiome for Obesity and Diabetes Management

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Microbiology in Human Health and Disease".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 3610

Special Issue Editors


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Guest Editor
Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
Interests: sertoli cells; insulin; diabetes; islet amyloids; transplantation immunology; genetic engineering; bioactive component

E-Mail Website
Guest Editor
1. Center of Excellence for Integrative Health, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
2. Obesity Research Institute, Texas Tech University, Lubbock, TX 79409, USA
Interests: diabetes; obesity; pancreas; islets; glucose homoeostasis

Special Issue Information

Dear Colleagues,

This Special Issue aims to comprehensively explore the multifaceted interplay between the gut microbiome and metabolic disorders, specifically obesity and diabetes. It seeks to consolidate and disseminate cutting-edge research, elucidating the role of the gut microbiota in the pathogenesis and progression of and the potential therapeutic interventions for these prevalent metabolic conditions.

Microbiome dynamics in metabolic disorders: investigating the intricate relationship between the gut microbiome and the development of obesity and diabetes, encompassing microbial composition, diversity, and functional alterations.

Modulation strategies: exploring diverse interventions targeting the gut microbiota, including dietary modifications, probiotics, prebiotics, fecal microbiota transplantation, and their impact on metabolic health.

Mechanistic insights: unraveling the underlying mechanisms and pathways through which gut microbial composition and activity influence obesity and diabetes onset, progression, and potential reversal.

Clinical implications: assessing the translational potential of microbiome-based interventions in clinical settings, evaluating their efficacy, safety, and long-term effects on managing obesity and diabetes.

Future directions: highlighting the gaps in current knowledge, identifying emerging trends, and proposing avenues for further research and innovative therapeutic strategies aimed at harnessing the gut microbiome for effective obesity and diabetes management.

This Special Issue invites original research, reviews, and perspectives from experts in the field, fostering a comprehensive understanding of the gut microbiome’s pivotal role in shaping metabolic health and paving the way for novel therapeutic interventions targeting obesity and diabetes.

Dr. Gurvinder Kaur
Prof. Dr. Jannette M. Dufour
Guest Editors

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Keywords

  • microbiome dynamics in metabolic disorders
  • modulation strategies
  • mechanistic insights
  • clinical implications
  • future directions

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Published Papers (1 paper)

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Review

33 pages, 2065 KiB  
Review
Dual Regulation Mechanism of Obesity: DNA Methylation and Intestinal Flora
by Yi Ren, Peng Huang, Lu Zhang, Yu-Fen Tang, Sen-Lin Luo, Zhou She, Hong Peng, Yu-Qiong Chen, Jin-Wen Luo, Wang-Xin Duan, Ling-Juan Liu and Li-Qun Liu
Biomedicines 2024, 12(8), 1633; https://doi.org/10.3390/biomedicines12081633 - 23 Jul 2024
Viewed by 3209
Abstract
Obesity is a multifactorial chronic inflammatory metabolic disorder, with pathogenesis influenced by genetic and non-genetic factors such as environment and diet. Intestinal microbes and their metabolites play significant roles in the occurrence and development of obesity by regulating energy metabolism, inducing chronic inflammation, [...] Read more.
Obesity is a multifactorial chronic inflammatory metabolic disorder, with pathogenesis influenced by genetic and non-genetic factors such as environment and diet. Intestinal microbes and their metabolites play significant roles in the occurrence and development of obesity by regulating energy metabolism, inducing chronic inflammation, and impacting intestinal hormone secretion. Epigenetics, which involves the regulation of host gene expression without changing the nucleotide sequence, provides an exact direction for us to understand how the environment, lifestyle factors, and other risk factors contribute to obesity. DNA methylation, as the most common epigenetic modification, is involved in the pathogenesis of various metabolic diseases. The epigenetic modification of the host is induced or regulated by the intestinal microbiota and their metabolites, linking the dynamic interaction between the microbiota and the host genome. In this review, we examined recent advancements in research, focusing on the involvement of intestinal microbiota and DNA methylation in the etiology and progression of obesity, as well as potential interactions between the two factors, providing novel perspectives and avenues for further elucidating the pathogenesis, prevention, and treatment of obesity. Full article
(This article belongs to the Special Issue Modulation of Gut Microbiome for Obesity and Diabetes Management)
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