Bioactive Lipids in Health and Diseases
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 331
Special Issue Editors
Interests: COX-2; liver; PGE2; mitochondria; inflammation; hypoxia; NAFLD; NASH; transplantation
Special Issue Information
Dear Colleagues,
Bioactive lipids, including arachidonic acid (AA) and its derivatives, are part of a complex network that modulates a plethora of cellular and molecular processes involved in health and disease, ranging from vascular function to gastric mucosa integrity, inflammation, and development/progression of non-alcoholic fatty liver disease, obesity, diabetes, cardiovascular disease, or even, as has recently been shown, COVID-19. Various phospholipases cleave membrane-bound AA that, once released, serves as substrate for three main routes: the cyclooxygenase, the lipoxygenase, and the cytochrome P-450 monooxygenase pathways. In particular, a complex interplay exists between mediators (belonging to the group of Eicosanoids) which induce the beginning of inflammation, such as prostaglandins (PGE2), leukotrienes (LT), and thromboxane A2 (TXA2), and molecules which display a key role in counteracting this process and in promoting its proper resolution. The latter group of mediators includes ω-6 arachidonic acid (AA)-derived metabolites, such as lipoxins (LXs), ω-3 eicosapentaenoic acid (EPA)-derived mediators, such as E-series resolvins (RvEs), and ω-3 docosahexaenoic (DHA)-derived mediators, such as D-series resolvins (RvDs), protectins (PDs), and maresins (MaRs), overall defined as specialized pro-resolving mediators (SPMs). The purpose of this Special Issue is to focus on bioactive lipids in the onset of metabolic and lipid disorders that can influence immune responses and inflammatory processes. We further discuss how the manipulation of these bioactive lipids emerges as a new therapeutic approach to prevent and treat many of the most prevalent diseases related to an increased inflammatory response.
Dr. Marta Casado Pinna
Dr. Daniel Eleazar Antonio Francés
Guest Editors
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Keywords
- bioactive lipids
- inflammation
- pro-resolving mediators (SPMs)
- eicosanoids
- prostaglandins
- leukotrienes
- metabolic diseases
- oxidative stress
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