Chronic Heart Failure: From Biomarkers to Targeted Therapies
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 609
Special Issue Editor
2. Faculty of Medicine, “Victor Babeş” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania
3. Research Centre of Timisoara Institute of Cardiovascular Diseases, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania
Interests: rehabilitation and follow-up of patients with heart failure; prevention of cardiovascular diseases; general cardiology
Special Issue Information
Dear Colleagues,
Congestive heart failure (CHF) remains a prevailing cause of morbidity and mortality worldwide, despite advances in pharmacological and device-based therapies. It is the final common pathway of various cardiovascular insults and is characterized by heterogeneous clinical presentations and outcomes. The increasing burden of CHF underscores the urgent need for improved strategies in diagnosis, prognosis, and individualized treatment.
This Special Issue aims to explore the evolving landscape of CHF, focusing on the integration of biomarkers and targeted therapies. Biomarkers have revolutionized the management of heart failure, offering critical insights into myocardial stress, inflammation, neurohormonal activation, and fibrosis. Their role in early detection, risk stratification, and therapeutic monitoring continues to expand.
Upon gaining a deeper understanding of heart failure pathophysiology, more targeted therapies that address specific molecular and cellular mechanisms have been developed. These include angiotensin receptor–neprilysin inhibitors (ARNIs), sodium/glucose cotransporter 2 (SGLT2) inhibitors, cardiac myosin activators, and agents targeting fibrosis and remodeling.
We welcome original research, reviews, and clinical studies that highlight innovations in biomarker discovery, validation, and application and the development and clinical impact of targeted therapies in CHF. We hope to foster multidisciplinary discourse that bridges basic science and clinical practice, ultimately improving patient outcomes.
Dr. Dana Emilia Man
Guest Editor
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Keywords
- biomarkers in heart failure
- GDMT in heart failure
- targeted therapies
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