Autophagy during Common Bacterial and Viral Infections
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 191
Special Issue Editor
Special Issue Information
Dear Colleagues,
Autophagy is a physiological process that maintains homeostasis and regulates the metabolism of every cell. The dysregulated operation of autophagy is of great pathogenetic significance in various bacterial and viral infections. Microbes are also known to affect the course of diseases by modifying autophagy in the cellular elements of the innate and adaptive immune systems. Some bacteria and viruses have developed escape strategies to avoid xenophagy. Other pathogens are endowed with the ability to affect autophagic processes in a sophisticated manner and thereby promote their intracellular multiplication. Although many valuable and exciting studies have shed light on the interactions between some infectious agents and the autophagic process, further investigations are needed to expand our understanding of the underlying molecular complexity, functional significance, and therapeutic potential. This Special Issue aims to gather novel observations on autophagy in vitro and in vivo models of common bacterial and viral infections. Research efforts elucidating how selected microbes, secreted bacterial virulence factors, or the microbiota regulate the autophagic process and how autophagy modifies the life cycle of intracellular pathogens will be considered valuable contributions. Studies identifying novel regulators implicated in the molecular mechanism, signaling, and transcriptional regulation of the autophagy of infected cells are especially welcome. An additional purpose of this Special Issue is to cover the role of autophagy in the antimicrobial immune response and the potential strategies for the therapeutic targeting of autophagy to resolve common bacterial and viral infections. Authors are welcome to submit their original research or review articles for this Special Issue.
Dr. Klara Megyeri
Guest Editor
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Keywords
- bacterial xenophagy
- viral xenophagy
- autophagic adaptors
- autophagic signaling
- bacterial structural components and toxins
- viral replication compartments
- autophagy-targeted antimicrobial therapy
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