Cutaneous Adverse Drug Reactions: Molecular Mechanisms and Clues for Intervention
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Drug Discovery, Development and Delivery".
Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 385
Special Issue Editor
Interests: xenobiotic metabolism; aryl hydrocarbon receptor; DNA repair; chemoprevention; skin cancer; skin aging; polycyclic aromatic hydrocarbons; ultraviolet radiation
Special Issue Information
Dear Colleagues,
Adverse drug reactions (ADRs) are unintended and harmful responses to one or more systemically administered drugs under normal conditions. Responsible for up to 10% of all hospitalizations, ADRs represent a common serious hazard for patients’ health, frequently requiring dose reduction, interruption or even discontinuation of the therapy. In addition, ADRs are responsible for a remarkably high attrition rate of new chemical entities of up to 90% and thus represent a major challenge for drug development. Hence, in addition to threatening the health and wellbeing of patients, ADRs are a substantial economic burden for both health care systems and pharmaceutical industry. In general, adverse skin reactions with clinical manifestations ranging from mild maculopapular rashes, urticaria, aberrant pigmentation, and photosensitivity to severe and life-threatening diseases, such as drug-induced hypersensitivity syndrome, toxic epidermal necrolysis, and Stevens–Johnson syndrome, are among the most common ADRs. Some of these adverse effects occur in a dose-dependent manner, others are driven by allergic reactions or are even idiosyncratic, for instance due to rare single nucleotide variations in genes encoding drug-metabolizing enzymes. The number of drugs that may cause adverse skin reactions is vast and thus emphasizes the urgent need for a better understanding of the key players, molecular events, and cellular pathways that facilitate the development of cutaneous ADRs.
This Special Issue aims to collect original research and review articles focusing on the molecular pathomechanisms of immunological and non-immunological cutaneous ADRs which might be targetable to protect patients’ health and improve drug development.
Dr. Thomas Haarmann-Stemmann
Guest Editor
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Keywords
- allergy
- cytochrome P450
- drug–drug interactions
- food–drug interactions
- haptens
- inflammation
- non-melanoma skin cancer
- photosensitization
- rashes
- T-cell receptors
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