Epigenetics in Congenital Diseases
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular Genetics and Genetic Diseases".
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 234
Special Issue Editor
Special Issue Information
Dear Colleagues,
The increasing availability of genome sequencing has significantly contributed to the identification of the genetic causes of many congenital diseases. However, it is often observed that individuals with the same genetic mutation exhibit varying degrees of disease severity. Moreover, certain congenital diseases have been sequenced, but no causal gene has been found. Epigenetics is a rapidly growing field that explores how gene expression is regulated without changes to the protein-coding DNA. These can include modifications in DNA, histone, or RNA that can alter protein expression. Studies suggest that epigenetic changes may account for the variability observed in individuals with the same genetic mutation, and, in some cases, could be the underlying cause of certain diseases.
This Special Issue will focus on recent advances related to epigenetics in congenital diseases. We invite submissions on a range of topics, including, but not limited to, epimutations, mutations in epigenetic regulators, mutations in gene regulatory regions, effects of environmental exposure on epigenetic modifications, novel techniques for assaying epigenetics in diseases, and the development of epigenetic therapies for congenital diseases.
Dr. Shifeng Xue
Guest Editor
Manuscript Submission Information
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Keywords
- epigenetics
- methylation
- histone
- congenital disease
- genetics
- environment
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