Insulin Resistance and Hyperinsulinemia: From Molecular Mechanisms to Clinical Translation
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".
Deadline for manuscript submissions: 31 March 2026
Special Issue Editor
Special Issue Information
Dear Colleagues,
Insulin resistance (IR) with associated hyperinsulinemia is a fundamental pathophysiological state at the center of a spectrum of disorders, including type 2 diabetes, obesity, cardiovascular disease, cellular senescence, cancer, and neurodegenerative diseases. Characterized by an impaired cellular response to insulin, IR disrupts glucose homeostasis, lipid metabolism, and inflammatory signaling, and is a driving force in the global health crisis.
This Special Issue, “Insulin Resistance and Hyperinsulinemia: From Molecular Mechanisms to Clinical Translation”, seeks to assemble cutting-edge original research and comprehensive reviews that illuminate the molecular foundations of IR and accelerate translational applications. We welcome submissions exploring the genetic, epigenetic, and environmental factors influencing insulin signaling pathways, as well as studies on the emerging roles of gut microbiota, adipokines, mitochondrial metabolism, and chronic inflammation in the onset and progression of IR.
A major emphasis will be on translational research bridging basic science with clinical practice. Contributions may address novel diagnostic strategies—including circulating biomarkers (e.g., microRNAs, metabolomics), advanced imaging methods, and early detection approaches—as well as therapeutic innovations such as SGLT2 inhibitors, GLP-1 receptor agonists, PPAR modulators, microbiome-targeted interventions, and precision medicine.
By uniting foundational insights with clinical advances, this Special Issue will provide an integrated perspective on IR, offering valuable guidance for both researchers and clinicians working to improve metabolic health outcomes worldwide.
Dr. Anindya Ghosh
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- insulin resistance
- type 2 diabetes
- metabolic syndrome
- obesity
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
